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PMCOL 305 Ecstasy Exam Latest Update
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PMCOL 305 Ecstasy Exam LatestUpdate
What year was ecstasy synthesized?Answer 1912
Who synthesized ecstasy?Answer Köllisch at Merck
Who published the first testing of ecstasy?Answer Alexander Shulgin
What year was the published first testing of ecstasy?Answer 1960
MDMA is extracted from what?Answer cured Ocotea pretiosa, Sassafras albidum, or
Cinnamomum parthenoxylon root bark
What percentage of safrole is in Sassafras HPLC essential oils?Answer 75-85%
Ecstasy is classified as what?Answer hallucinogen
Ecstasy is similar to what?Answer mescaline
What shifts stimulant effects toward mood and perceptions?Answer Methylenedioxy
ring
How is an MDMA tablet absorbed?Answer ingestion
How is Molly powder absorbed?Answer insufflation
What is a typical dose of MDMA?Answer 75-100mg
What organs is MDMA distributed to?Answer - brain
- lung
- liver
- kidney
- spleen
What is the onset of MDMA?Answer 30-45 min
What is the duration of MDMA?Answer 4-6 hour
What is the therapeutic index of MDAM?Answer 14-16
What enzyme metabolizes MDMA?Answer CYP2D6
, What is the half life of MDMA?Answer 6 hours
What percent of the MDMA is degraded by CYP2D6?Answer 80%
How is MDMA excreted?Answer kidneys
What are acute effects of MDMA?Answer - empathogen
- entactogen
- euphoria
- emotional empathy
- energy
What are the sympathomimetic acute effects of MDMA?Answer - increased heart rate
- hyperthermia
- diaphoresis
What does the 5HT (1B/2) agonist cause?Answer - jaw grinding
- increased locomation
Reverses of 5HT transporter may also involve what?Answer TAAR
Which transporters are blocked in the physiological mechanisms of MDMA?Answer NE
and DA
MDMA causes increases of what in the brain?Answer - DA
- prolactin/oxytocin
- cortisol
The increase of prolactin/oxytocin is due to what?Answer 5HT
What is the increased prolactin/oxytocin involved with?Answer bonding and empathy
What percentage of cortisol is increased?Answer 800%
What does the increased cortisol correlate with?Answer - excitement
- happiness
- increase of blood glucose
Does MDMA shift activation towards or away from the amygdala?Answer away
Does MDMA shift activation towards or away the ventral striatum?Answer towards
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