Adaptive immunity: - correct answer...✔✔Follows innate immunity if unsuccessful.
Memory immunity, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses)
Define mutations - correct answer...✔✔Variations in the nucleotide sequence of a gene
3 main goals of treatment: - correct answer...✔✔Cure
Control
Palliation
Define neoadjuvant therapy - correct answer...✔✔Treatment is given prior to surgery to
shrink the tumor
Define adjuvant therapy - correct answer...✔✔Additional cancer treatment given after
the primary treatment to lower the risk that the cancer reoccur
Define conditioning/preparative therapy - correct answer...✔✔Treatments used to
prepare a patient for stem cell transplantation
AGRADESOLUTIONS
, 2 types of conditioning therapies: - correct answer...✔✔Myeloablative
Nonmyeloablative
Define dose density - correct answer...✔✔Drug dose per unit of time
Define dose intensity - correct answer...✔✔Amount of drug delivered over time
How is relative dose intensity (RDI) calculated? - correct answer...✔✔By comparing the
dose that the patient ACTUALLY received to the planned dose of the standard regimen
How do alkylating agents work? - correct answer...✔✔By causing a break in the DNA
helix strand, interfering with DNA replication and causing cell death
3 subcategories of alkylating agents: - correct answer...✔✔1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - correct answer...✔✔Nitrogen
mustards
Hypersensitivity can occur with late doses of: - correct answer...✔✔Carboplatin
These agents are typically categorized as highly emetogenic: - correct answer...✔✔1.
Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - correct answer...✔✔
BUN
Creatinine
CBC w/ diff
AGRADESOLUTIONS
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