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PMCOL 371 Final Exam Study Guide
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PMCOL 371 Final Exam StudyGuide
Orthodromic Response - Answer stimulate presynaptic fibers, record postsynaptic
response.
NPY inhibits Glu release (synaptically mediated action potentials)
Antidromic Response - Answer Stimulate postsynaptic axons, observe cell body
response
Sharp Microelectrode - Answer fine glass tip filled with strong salt. DC coupled
amplifier. Sub-threshold activity.
Wheatstone Bridge - Answer balances resistances of pipette and bridge to neutralize
effect of pipette resistance. Initial response reflects only cell membrane properties.
Cell-autonomous Bursting - Answer rhythmically depolarize even after isolation
Network Based Burst - Answer Two tonic or no activity cells if active generate rhythm
due to mutual antagonist synaptic inhibition (inhibitory synapses)
Command Neuron - Answer Tonic firing neuron, sensory input to get a not intrinsically
rhythmic circuit going
Trigger Neuron - Answer Trigger rhythmicity of network.
Snail CPG - Answer RPeD1, VD4, IP3I
IP31 - Answer activation of VI/J
RPeD1 - Answer Destroy CB, CPG fin for awhile. All signaling in dendrite and axons, only
ITM is shown, no LTM.
STG - Answer CPG, STG, STNS
Gastric Mill CPG - Answer Gpn, agn, lpgn, dgn
bursting irregular (except gpn), phasic relationship between them
Pyloric CPG - Answer Pdn, avn, lpn, pyn, myn (AB, PD, LP, PY)
faster then mill, regular bursting with phasic relationships
AB and PD connected by gap junctions. Depolarization in AB/PD lead to LP
hyperpolarization.
, LPG - Answer regular fast bursting with pyloric activity and gastric silence
slow rhythm when gastric active indicative of DG cell activity
Apamin and Motor CPG - Answer block AHP K/Ca, prolong duration, perturbs regularity
of antagonistic nerves in SC.
Mammal CPG - Answer In vivo slower, require 5-HT, NMDA, DA. Rostral CPG stronger
than caudal, synaptic excitatory drive.
Breathing CPG - Answer preBotC: inspiratory
pFRG: expiratory
pFRG - Answer short pre-inspiratory activity, silent during inspiratory, strong
post-inspiratory activity.
preBotC - Answer slow bursting -57, tonic past -47.
Breathing Currents - Answer INa (slow inactivating), activate IKCa (AHP), ongong tonic
excitatory drive restarts breathing with positive Glu feedback.
Protein Kinases - Answer CaMKII and PCK: activation induce LTP
MAPK: activated by LTP, inhibit late gene expression
PKA and Tyrosine Kinase: specific pathways
Feedback Somatic Inhibition - Answer output axon excites interneuron that feedback
and inhibit CB
Feedforward Somatic Inhibition - Answer Input axon excites inhibitory interneuron prior
to pyramidal neuron inhibiting CB. Curtail early excitation.
Feedforward Dendritic Inhibition - Answer Input axon excites inhibitory interneuron after
pyramidal neuron inhibiting dendrite. GABAb slow activating stops activity eventually.
Feedback Dendritic Excitation - Answer 2nd Pyramidal neuron feedback onto 1st
exciting the dendrites
Feedforward Dendritic Excitation - Answer 1st pyramidal neuron feed forward onto 2nd
causing a second AP as it beats GIRK.
Non-linear Summation - Answer more than additive. non-NMDA activation creates
stronger NMDA excitation
ChR2 - Answer Na and Ca, 473nm
VChR1 - Answer Na and Ca, 530-570nm
Arch - Answer H efflux, 532nm. Halorubrum sodomense
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