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PMCOL 344 Hematopoietic Exam Latest Update
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PMCOL 344 Hematopoietic ExamLatest Update
Hydroxocobalamin - Answer Vitamin B12 therapy to treat anemia
Darbopoietin - Answer Hyper-glycosylated form of Epo (recombinant human
erythropoietin), longer half-life than others
CERA - Answer Continuous erythropoietin receptor activation -> post-translationally
modified epoietin beta, linked to polyethylene glycol which prolongs its half-life to 6
days.
Recombinant Epo fusion proteins - Answer Epo (peptide) fused to Fc portion of human
IgG -> administered by inhalation
Epo mimetic peptides (EMPs) - Answer Small cyclic synthetic products (~20 aa) linked to
polyethylene glycol - possible CV risk
Acetyl salicylic acid - Answer Irreversibly iTinhibits COX1+2, preventing formation of
TXA2, decreasing platelet aggregation but has several side effects. NSAID.
Ticlopidine - Answer Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on
P2Y12 receptors (which usually promote platelet aggregation). Can cause neutropenia
and thrombocytopenia.
Clopidogrel - Answer Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on
P2Y12 receptors (which usually promote platelet aggregation). Fewer serious effects
than others and usually used by ASA intolerant individuals.
Prasugrel - Answer Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on
P2Y12 receptors (which usually promote platelet aggregation). Fastest
biotransformation to active metabolite so more efficatious (but also more risk of
bleeding)
Ticagrelor - Answer Reversible allosteric P2Y12 antagonist, NOT a thienopyridine, not a
pro-drug. Side effects include dyspnea and bradyarrhythmia.
Dual anti-platelet therapy (DAPT) - Answer ASA and clopidogrel OR ticagrelor, up to one
year following MI and one month following cerebrovascular stroke
Dipyridamole - Answer Cyclic nucleotide PDE inhibitor, blocks adenosine uptake (wear
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