100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
PMCOL 344 Hematopoietic Exam Latest Update $11.99   Add to cart

Exam (elaborations)

PMCOL 344 Hematopoietic Exam Latest Update

 12 views  0 purchase
  • Course
  • PMCOL 344 Hematopoietic
  • Institution
  • PMCOL 344 Hematopoietic

PMCOL 344 Hematopoietic Exam Latest Update ...

Preview 1 out of 3  pages

  • September 10, 2024
  • 3
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • PMCOL 344 Hematopoietic
  • PMCOL 344 Hematopoietic
avatar-seller
Zayla
PMCOL 344 Hematopoietic Exam
Latest Update

Hydroxocobalamin - Answer Vitamin B12 therapy to treat anemia

Darbopoietin - Answer Hyper-glycosylated form of Epo (recombinant human
erythropoietin), longer half-life than others

CERA - Answer Continuous erythropoietin receptor activation -> post-translationally
modified epoietin beta, linked to polyethylene glycol which prolongs its half-life to 6
days.

Recombinant Epo fusion proteins - Answer Epo (peptide) fused to Fc portion of human
IgG -> administered by inhalation

Epo mimetic peptides (EMPs) - Answer Small cyclic synthetic products (~20 aa) linked to
polyethylene glycol - possible CV risk

Acetyl salicylic acid - Answer Irreversibly iTinhibits COX1+2, preventing formation of
TXA2, decreasing platelet aggregation but has several side effects. NSAID.

Ticlopidine - Answer Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on
P2Y12 receptors (which usually promote platelet aggregation). Can cause neutropenia
and thrombocytopenia.

Clopidogrel - Answer Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on
P2Y12 receptors (which usually promote platelet aggregation). Fewer serious effects
than others and usually used by ASA intolerant individuals.

Prasugrel - Answer Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on
P2Y12 receptors (which usually promote platelet aggregation). Fastest
biotransformation to active metabolite so more efficatious (but also more risk of
bleeding)

Ticagrelor - Answer Reversible allosteric P2Y12 antagonist, NOT a thienopyridine, not a
pro-drug. Side effects include dyspnea and bradyarrhythmia.

Dual anti-platelet therapy (DAPT) - Answer ASA and clopidogrel OR ticagrelor, up to one
year following MI and one month following cerebrovascular stroke

Dipyridamole - Answer Cyclic nucleotide PDE inhibitor, blocks adenosine uptake (wear

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller Zayla. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $11.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

75323 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 14 years now

Start selling
$11.99
  • (0)
  Add to cart