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PMCOL 343 Drugs Study Set Exam
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PMCOL 343 Drugs Study Set Exam ...
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PMCOL 343 Drugs StudySet Exam
Thioamides - Answer inhibit TPO
block orgnaification and coupling
inhibition of peripheral T4-> T3 conversion
adverse - cause agranulocytosis
slow clinical response
radioactive iodine - Answer 127 - emits gamma rays - used for imaging
131 - gamma + beta
has cytotoxic action - destruction of follicle cells
onset 1-2 months
localized action
may develop hypothyroidism
iodide/iodine - Answer inhibits organifcation/proteolysis
thyrotoxic cells and before surgery
reduces gland size and vascularity
rapid improvement
disadvantage
- delay in response to thioamide or radioactive I
- temporary inhibition
- can cause thyrotoxicosis upon WD
anion inhibitor - Answer CLO4-
competitive inhibitor of NIS
reduce iodide uptake
, can be overwhelmed by high iodide concentration
Beta-adrenergic antagonists - Answer Propanolol
antagonize the sympathetic effects of thyrotoxicosis
reduce tachycardia, arrhythmia, tremor and anxiety
use
- prep for surgery
- initial treatment of hypothyroidism
Guanethidine - Answer noradrenergic blocker
used to relieve exophthalmos
relaxation of symp innervated SM that causes eyelid retraction
Tamoxifen - Answer partial agonist inhibitor of estrogen receptors
estrogenic effects:
- bone
- plasma lipids
- endometrium
- blood coagulation
Anti estrogenic:
- breast tissue
- treatment of breast cancer or to prevent cancer in high risk women
non ER- mediated
- modulation of signalling proteins
- activation of apoptosis
steroidal or non steroidal inhibitor
selective inhibition of estrogen synthesis
first line of treatment for breast cancer (+tamoxifen)
no increased risk of uterine cancer or thromboembolism
no beneficial effect on bone - Answer Aromatase inhibitors
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