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PMCOL 343- Pain I Study Set Exam
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PMCOL 343- Pain I StudySet Exam
What type of perception do A-beta fibres play a crucial role in - Answer Perception of
light touch; these fibres are highly sensitive to light touch and convey information about
tactile sensations
Describe the extent of myelination of A-beta fibres - Answer Heavily myelinated
What type of perception do A-delta fibres play a crucial role in - Answer Perception of
signals related to sharp and acute pain
Describe the extent of myelination of A-delta fibres - Answer Myelinated, but less than
A-beta fibres
What type of perception do C fibres play a crucial role in - Answer Perception of dull,
persistent pain signals (heat and chemical stimuli)
Describe the extent of myelination of C fibres - Answer Unmyelinated
Rank A-beta, A-delta, and C fibres from slowest impulse conduction to fastest impulse
conduction - Answer C fibres (slowest), A-delta fibres, A-beta fibres (fastest)
Where are the cell bodies for A-beta, A-delta, and C fibres located - Answer In the dorsal
root ganglion
These sensory neurons have long projections that extend into what two direction -
Answer One projection extending to peripheral tissues to detect sensory stimuli, and the
other extending into the spinal cord
When a painful stimulus is present, what type of receptor in the peripheral tissue is
activated, and what happens when these are activated - Answer Nociceptors; when
activated they generate action potentials
The action potentials caused by nociceptor activation is then travelled along through
pain fibres to what location - Answer The dorsal root ganglion
The sensory information from the dorsal root ganglion enters the spinal cord through
what type of neurons - Answer Dorsal root projecting neurons
What happens once the pain signal is in the spinal cord - Answer It crosses over to the
other side, and is then transmitted to higher brain centres
, What happens to the pain signal once it is in these higher brain centres - Answer Pain
signal is processed and interpreted, leading to the conscious perception of pain
What is the definition of nociception - Answer The neural encoding of a noxious signal
What is the definition of pain - Answer The unpleasant experience associated with tissue
damage; more psychological (how that nociception affects you)
What is the definition of an analgesic - Answer Selectively blocks the sensation of pain,
without blocking other modalities
What is the definition of a local anesthetic - Answer Blocks nerve conduction and all
sensation in a localized area
What is the definition of a general anesthetic - Answer Induces a reversible loss of
consciousness
General anesthetics do not always cause analgesia; describe what this means - Answer
Provides for intraoperative analgesia, but additional measures are usually required for
postoperative analgesia
What is the definition of hyperalgesia - Answer The enhanced response to a painful
stimuli
What is the definition of allodynia - Answer The generation of a painful response by what
is considered an innocuous stimulus (generation of pain from a non-painful stimuli)
Describe what the term 'good pain' refers to - Answer The pain response is important for
our existence, as it serves a protective function and biological purpose (ie. protection
from tissue damage)
Acute pain is generally carried by A-delta fibres; what fibres would carry the information
if the injury led to more persistent pain - Answer Would be carried by C-fibres
What is the most common treatment for mild, musculoskeletal pain - Answer Typically
with non-steroidal anti-inflammatory drugs (like aspirin or ibuprofen)
Persistent pain is caused mainly by the release of what three inflammatory mediators -
Answer Bradykinin, histamine acid metabolites, and prostaglandins
What does the term 'deep pain' refer to - Answer Pain that originates from structures
located deeper within the body, as opposed to pain from superficial tissues
What is the most common treatment for deep pain - Answer With the use of major
analgesics, such as morphine (an opioid)
Deep pain is still considered 'good pain'; describe why - Answer Deep pain still plays a
protective role, allows for the healing process to progress and prompts the individual to
take actions to avoid further damage
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