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Abnormal RBCs Exam Questions with complete solutions 2024/2025( A+ GRADED 100% VERIFIED).
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Abnormal RBCs Exam Questions with complete solutions 2024/2025( A+ GRADED 100% VERIFIED).
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Abnormal RBCsBite Cell Formation
3 mechanisms of spherocytes
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Abnormal RBCs
Spherocytes
Small, round, dense RBC with no central pallor
found in: Hereditary Spherocytosis, Immune hemolytic anemia, extensive
burns(as well as schistocytes)
Burr cells
or echinocytes
RBC with blunt or pointed, short projections that are usually evenly spaced over
the surface of the cell; present in all fields of the blood film, but in variable
numbers per field.
Found in Uremia, and Pyruvate kinase deficiency
, Target Cells
or codocyte
RBC with hemoglobin concentrated in the center and around the periphery
resembling a target.
Found in Liver disease, hemoglobinopathies, Thalassemia
Ovalocytes
Can be micro(<6 um, MCV <80 fL) or macrocytic
Found in: Megaloblastic anemia, Iron deficiency anemia, anemia of chronic
inflammation, sideroblastic anemia, thalassemia, HbE disease and trait
Poikilocytosis
Abnormal variation in RBC shape
Found in: Severe anemia, certain shapes helpful diagnostically
Elliptocyte or Ovalocyte
Elliptical (cigar shaped) or Oval (egg shaped)
Found in: Hereditary elliptocytosis or ovalocytosis
Iron deficiency anemia, Thalassemia Major, Myelophthisic anemia
Stomatocytes
RBC with slit like area of central pallor
Found in: Hereditary stomatocytosis
Rh deficiency syndrome
Acquired stomatocytosis (liver disease alcoholism)
Artifact
Sickle Cell
Thin, dense, elongated RBC pointed at each end, may be curved
Found in: Sickle cell anemia, Sickle cell Beta-thalassemia
Hb C crystal
Hexagonal crystal of dense hemoglobin formed within the RBC membrane
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