Anemia and RBC Disorders
The ____ is a basic screening test and is one of the most frequently ordered
laboratory procedures. Series of blood cell tests that determines their:
complete blood count (CBC) - determine
number, • variety • percentage • concentrations and • quality
the 3 main components of the CBC with differential are
rbc and indices
wbc and differential
platelet count
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It is important to remember that the "normal" values for a CBC can be affected by
several factors including the patient's:
age
race
sex
Red blood cells (RBCs) (also called erythrocytes) are the ___ cellular component
of blood comprising about 40 - 45% of ___, and 99.9% of ___ blood elements.
largest
,total blood volume
formed
RBCs contains the red, iron-based protein ___ which binds and transports O2
and CO2 . RBC contains 4 molecules of ___, each molecule contains one ___ and
4 molecules of ___ consisting of 2 ___ chains, and 2 ___ chains
hemoglobin
heme
iron (Fe2+) ion
globin
alpha
beta
each rbc is a ___ shape that provides an increased __ for o2 and co2 transfer. It
enables them to ___ and __ when they enter small capillaries. Mature RBCs lack
___. RBCs normally survive about __ days in the blood before they are removed
primarily by the ___.
biconcave disk
surface area
bend and flex
a nucleus and most cellular organelles.
120
spleen
Red blood cell count (RBC or erythrocyte count), whole blood is the total number
of ____. What factors affect RBC count?
RBCs per unit volume of whole blood
exercise, age, altitude, pregnancy, and many drugs
Secondary polycythemia (e.g. secondary to cardiovascular disease, COPD),
hemoconcentration (dehydration), polycythemia vera will cause the rbc to?
elevate
RBC count may be decreased in:
, Anemia, chronic or acute blood loss, fluid overload, bone marrow
suppression/disease, etc
Hematocrit (HCT) (also known as packed cell volume [PCV] or erythrocyte volume
fraction [EVF]) is the ____ of red blood cells in whole blood. Hematocrit can also
be calculated by multiplying the RBC count by the ___
volume percentage (%)
mean corpuscular (cell) volume (MCV).
Physiologic variants that effect outcomes include ____Hematocrit may be
increased in ____.
Age, pregnancy, many drugs
Any condition that increases RBCs including hemoconcentration (as in
dehydration, severe burns, vomiting, diarrhea), polycythemia (erythrocytosis),
extreme physical exercise, etc
Hematocrit may be decreased in ____.
Many conditions that decrease RBCs including anemia, hemodilution, acute
hemorrhage, bone marrow suppression/disease, etc
___ is the amount of hemoglobin in a given volume of whole blood. Factors that
affect it's level include
Hemoglobin, total, whole blood (Hgb or Hb)
Age, high altitude, excessive fluid intake, pregnancy, and many drugs.
hgb may be increased in?
Hemoconcentration (as in dehydration, severe burns, vomiting), polycythemia
(erythrocytosis), extreme physical exercise, hyperlipidemia, etc.
Hemoglobin may be decreased in?
Many conditions that decrease RBCs including anemia, hemodilution, acute
hemorrhage, bone marrow suppression/disease, etc