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GMS6504 Exam 2 Questions And Correct Answers Graded A+
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GMS6504 Exam 2 Questions And CorrectAnswers Graded A+
-NH2
Which of the following functional groups is a hydrogen bond donor according to
Lipinski's rules?
High
Hydrophobic molecules will have a high or low lopO
It helps the drug cross the blood brain barrier
What is the best explanation as to why drugs of the CNS tend to have smaller polar
surface areas than drugs that target things outside of the CNS?
Esters
Which functional group is most commonly used when preparing prodrugs?
ATP-binding domain
Which of the following protein domains would you expect to find in an "easily druggable"
target but NOT in an "undruggable" target?
Amplify
Would administration of cells with a synthetic lethal-inducing drug tend to increase or
decrease its therapeutic index?
PARP
Inhibition of which enzyme is expected to induce synthetic lethality in a cell bearing a
mutation in BRCA2?
Phosphates
Kinases transfer which functional group to proteins?
GIGSAG
Which of the following sequences could be that of the catalytic site of a kinase?
Methionine
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