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Red Blood cells & disorders Exam Questions and Answers( A+ GRADED 100% VERIED).
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Red Blood cells & disorders Exam Questions and Answers( A+ GRADED 100% VERIED).
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Red Blood cells & disordersMain components of RBC:
-RBC membrane
-Hemoglobin (2 α- and 2 β-chains)
Each chain of hemoglobin contains _____________
Iron (Heme group)
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Function of RBC membrane:
-maintain RBC structure
-carry RBC antigens
-Function as receptors or transport proteins
Primary composition of RBC membrane :
-Semipermeable lipid bilayer
,-Mesh-like cytoskeleton structure
-Membrane proteins
Function of hemoglobin:
-Delivery & release of oxygen to tissues
-Facilitate CO2 Excretion
4 factors that affect the affinity of hemoglobin for oxygen:
-Abnormal hemoglobin
-pH
-Temperature
-DPG (2,3-diphosphoglycerate)
A conjugated globular protein of Hemoglobin consists of :
-Globin: a tetramer of 2 pairs of α & β chains)
-4 Heme groups (each group contains protoporphyrin ring and ferrous iron
(Fe2+))
Synthesis of hemoglobin is dependent on : (3)
-Adequate Fe delivery and supply
-Adequate synthesis of Protoporphyrins (precursor of heme)
-Adequate Globin synthesis
Deficiency in Fe in hemoglobin results in _______________
Iron deficient anemia
Blocked synthesis of Protoporphyrin of hemoglobin results in _______________.
Metabolic disorders
, → "Porphyrias"
Abnormality in globin synthesis in hemoglobin results in _______________.
Hemoglobinopathies (e.g. sickle cell anemia)
______________ is a precursor of heme.
Protoporphyrin
______________ : increase in # RBC
______________ : reduction in oxygen transporting capacity of blood.
Polycythemia
Anemia
Suffix "-cytosis" means :
Increase in number of cells
3 Main reasons that lead to Anemia:
1) Excessive bleeding
2) Increased RBC destruction (hemolytic disorders)
3) Decreased RBC production (Hypoproliferative disorders)
Anemia is a reduction in ability to __________________, due to
___________________.
Transport oxygen in blood ;
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