1. First 5 steps in the inflammatory process: 1. mast cell degranulation
2. activation of coagulation cascade
3. activation of kinin cascade
4. release of chemotactic factors
5.Activation of the complement
cascade
2. Role/function in the inflammatory process: Complement: Form the
mem- brane attack complex
bacterial
lysis
vasodilatio
n
Increased vascular
,permeability triggers mast
cell degranulation
chemotaxis
opsonization - opsonins tag foreign pathogens for elimination by
phagocytes
3. Role/function in the inflammatory process: kinin: turned into bradykinin
which is responsible for pain, chemotaxis and Increased vascular
permeability and vasodi- lation
4. Role/function in the inflammatory process: Coagulation cascade: plays
role in activating the kinin system
Factor XII (Hagemon factor) activates kinin and forms a fibrin mesh to
stop bleeding and trap microorganisms
5. Role/function in the inflammatory process: chemotactic factors: once
re- leased attract neutrophils, eosinophils and monocytes for
phagocytosis
,6. Role/function in the inflammatory process: Neutrophils: show up at the
site of injury in 6-8 hours
Neutrophils express and release cytokines, which in turn amplify
inflammatory reactions by several other cell types. In addition to
recruiting and activating other cells of the immune system,
neutrophils play a key role in the front-line defense against invading
pathogens.
7. Role/function in the inflammatory process: monocytes: Show up in 1-7
days become macrophages
present antigens to the CD4 cell which leads to Tcell immunity which
leads to B cell immunity
Releases IL1, IL6, TNF and growth factors
8. Role/function in the inflammatory process: Mast cell degranulation:
triggers the activation of the acute phase reactants
This leads to the release of histamine, cytokines, leukotrienes,
, platelet activation factor and prostaglandins
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