Anti-infectives therapeutic effects
~~> The goal is interference with the normal function of the invading
organism to prevent it from reproducing and to cause cell death
without affecting host cells
What do anti-infectives do?
~~> The goal of antiinfective therapy is the reduction ...
✓ ~~> Because of the emergence of resistant bacterial strains and the
development of newer antibiotics, the sulfa drugs are no longer used
much. However, they remain an inexpensive and effective treatment
for UTIs and trachoma, especially in developing countries and when
cost is an issue
Gram Negative/ Aminoglycosides priorities
✓ ~~> Ensure that the patient receives a full course of aminoglycoside
as prescribed, divided around the clock, to increase effectiveness and
decrease the risk for development of resistant strains of bacteria.
Monitor the patient regularly for signs of nephrotoxicity, neurotoxicity,
and bone marrow suppression to effectively arrange for
discontinuation of drug or decreased dose, as appropriate, if any of
these toxicities occurs
Antibiotics that are selectively toxic?
✓ ~~> -Vancomycin's use is reserved for special situations as it may be
highly toxic and can cause renal failure, ototoxicity, and
superinfections.
-selective toxicity, which is the ability to affect certain proteins or enzyme
systems used only by the infecting organism but not by human cells. Because
Master01 | September, 2024/2025 | Latest update
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