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Chemistry in everyday life
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,↓Drugs are chemical of low molecular mass (v100-5000) ·
These interact
with macromolecular targets and produce a
biological response , when
Bio response is therapeutic and useful these chemicals are called Medicine -
,
2
Drugs
.
L > >
Pharmological
effect
Drigation Chemical
snucture
molecular
targets
It is useful for
·
. Drug action on a Ammon Structure
· ·
Based on molecular
doctors Particular biochemical Often have
Similar target is most
process Pharmalogical useful classification
activity for medicinal
Chemist
·
Sulphonamide. have
common Structure
3
.
Catalysing action of
enzyme
:
·
First the enzyme holds the substrate for a chemical
reaction in the active . So
site it can be attacked
by reagent effectively
·
Substrate binds to active site by H-bond ,
joric bond ,
Vander waal or
dipole-dipole interaction .
, Second function
·
of
enzyme
is to provide functional group
that will attack the substrate and out chemical
carry
vexu .
4
. Competitive inhibitor :
Drugs compete with natural substrate for their attachment
on the active sites of . Such
enzymes drugs are called
Competitive inhibitor .
.
5
non-competitive inhibitor :
These bind to allosteric site
drugs
·
·
The binding at allosteric Site Changes the
Shape
of the active site in Such a
way that substrate
Cannot recognise it.
·
If the boud formed blu an
enzyme and inhibitor
is a
strong covalent bond , then it cannot be broken
easily ,
then the enzyme is blocked permanently
.
then the body
·
degrades the enzyme-inhibitor
complex and produces a new enzyme .
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