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SBCP – LIFESPAN Test with Questions and 100% Correct Answers
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SBCP – LIFESPAN Test with Questions and 100% Correct Answers
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SBCP – LIFESPAN Test withQuestions and 100% Correct Answers
What is teratogenesis - Answer Drugs that can cause birth defects
Teratogenesis overview - Answer Breastfeeding risk
Lipid soluble cross most readily
Poorly understood
Teratogenesis recommendations - Answer Take meds after breastfeeding
Avoid sustained-release meds
Drugs that tend to be excluded from milk
Geriatric (>65yr) key issues - Answer Altered pharmacokinetics
↑ fat - more drug stored
↓ blood volume - drug concentration greater
↓ body mass - greater conc. to target
↓ albumin - more free drug
Longer half lives
, ↓ renal function
poor adherence
Disease states - Answer Kidney
Liver
Acid/base imbalance
altered electrolyte status
Kidney - Answer Responsible for the elimination of drugs via active transport
Uncharge drug
↓Renal function = ↓elimination = ↑and extended plasma levels Albumin loss =
less protein binding
Liver - Answer • Major site of drug metabolism = improved renal drug excretion
• Short term: induction or inhibition of liver enzymes of liver enzymes =
changed metabolism rates
• Long term (Liver damage) = ↓ rate of metabolism = ↑persistence and
plasma levels
• Also ↓rate of albumin production = ↑ free drug
Acid/Base Imbalance - Answer • Drugs designed to behave at body's normal pH
• Alterations can cause a drug to ionise - ions don't cross BBB easily
Altered Electrolyte status - Answer • Affect physiology e.g. nerve signalling,
membrane pumps
• Drug effects less common but serious
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