100% satisfaction guarantee Immediately available after payment Both online and in PDF No strings attached
logo-home
Previously searched by you
Previously searched by you
logo
Bioinformatics and Computational Biology Final Exam || With Questions & Answers (Graded A+) $12.99
Add to cart
Quickly navigate to
Preview
  2.  
  3. Bioinformatics And Computational Biology
  4.  
  5. Bioinformatics and Computational Biology

Exam (elaborations)

Bioinformatics and Computational Biology Final Exam || With Questions & Answers (Graded A+)
 0 purchase
  • Course
  • Bioinformatics and Computational Biology
  • Institution
  • Bioinformatics And Computational Biology

Bioinformatics and Computational Biology Final Exam || With Questions & Answers (Graded A+) Bioinformatics and Computational Biology Final Exam || With Questions & Answers (Graded A+) What is Bioinformatics? - ANSWER - Bioinformatics is an interdisciplinary science to compile, store, and analy...

[Show more]

Preview 3 out of 20  pages

Document information

  • September 13, 2024
  • 20
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • bioinformatics and computational biology final exa
  • how to calculate the length of a gene and its prot
  • what 2 proteins would be good on the
  • what are the three torsion angles and explain thei

Written for

  • Bioinformatics and Computational Biology
  • Bioinformatics and Computational Biology

Seller

avatar-seller
conceptialresearchers

Reviews received

Content preview

Bioinformatics and
2024 Computational Biology
Final Exam || With
Questions & Answers
(Graded A+)




Conceptial Researchers ||


, Bioinformatics and Computational
Biology Final Exam || With Questions &
Answers (Graded A+)
What is Bioinformatics? - ANSWER - Bioinformatics is an interdisciplinary science to
compile,
store, and analyze/mine biological and medical data to help solve problems to
improve human health and well‐being

Differences between bioinformatics and computational biology - ANSWER -
Bioinformatics focuses on storage and analysis
of biological and medical data. Computational Biology is focused on modeling of
biological processes

Information used to propose the double helix DNA structure model by Watson and
Crick in 1953 - ANSWER - Rosalind Franklin's X-ray data. Electronegativity? ???
Chargaff's Rule?

What is the central dogma of molecular biology? Esp. its most important highlight -
ANSWER - DNA to RNA to Proteins. (With back and forth). Highlight is that once info
has gotten into a protein, it can't get back out again.

Structural integrity of DNA double-helix; why DNA basepairs are not possible
between purines only or between pyrimidines only? - ANSWER - Bonds need to be a
certain length. Purine:purine is too close, Pyrimidine:pyrimidine is too far.

The numbering system of DNA/RNA nucleotides (you learned this in lab) - ANSWER
- Pyrimidines start at 1 at Nitrogen connected to sugar. Counter-clockwise to double-
bonded oxygen. Purines start at top-right nitrogen, going clockwise on first ring. Left
ring continues with 7 at top, going counter-clockwise, finishing with bonding to sugar
at 9.

How does DNA replication and duplication differ? - ANSWER - DNA Replication: the
semi‐conservative copying process of entire DNA from its original DNA before cell
division

DNA Duplication: a process to duplicate a chromosomal region

IUPAC‐IUB symbols for nucleotides; study the detailed correspondences - ANSWER
- Examples: 1:1 A Adenosine (G Guanine etc)
1:2 R means A or G (Purine)
Y means C or T (Pyrimidine)
M[K]=amino group at C6 (A or C)
K[M]=Keto group at C6 (G or T)
S[W]=Strong HB (C or G)
W[S]=Weak HB (A or T)
1:3 B [A] exclusive of A

, D [C] exclusive of C
H [G] exclusive of G
V [U] exclusive of U
1:4 N any nucleotide

Complexity of eukaryotic gene expression - ANSWER - basically the central dogma.
coding->template->transcription->capping->slicing introns
->translation->post-translational modification

How DNA replication leads to changes or mutation? (discussed in class) - ANSWER
- Mutations can be caused by environmental factors such as ultraviolet radiation from
the sun, or can occur if a mistake is made as DNA copies itself during cell division.
Most DNA replication errors are caused by mispairings of a different
nature/inappropriate bonding (A with G).

Sugar puckering patterns: C3'‐endo and C2'‐endo - ANSWER - Pucker mean it bend.
C3 mean 3 carbon location. C2 mean 2 carbon location. yay.
A-DNA and A-RNA are C3endo
B-DNA is C2endo

Meanings of terminologies in DNA/genome sequencing; read, contig, scaffold, and
assembly - ANSWER - (Questionable)
read=sequence data
contig=overlapping sequence datas (reads)
Scaffolds consist of overlapping contigs separated by gaps of known length
Assembly is everything overall putting it together to make a genome (the two
methods etc)

How to calculate the length of a gene and its protein product; how to write fragments
of the
final protein product using the 1‐letter codes of amino acids; carefully think about a
gene finding
algorithm!
Ex: Assume that the genome in each human cell is 3 billion basepairs (bp) in length
and an average adult has 70 trillion cells in the body. Considering that the rise per
basepair in DNA structure in a cell is 3.00 Ångstrom, calculate and report the total
DNA length in the body in kilometers (km) - ANSWER - 63 billion km? do the math


One letter codes are gross.
gene finding algorithm?
Given a sequence, local alignment algorithms such as BLAST, FASTA and Smith-
Waterman (gene prediction)

3‐letter and 1‐letter codes of 20 amino acids and their classification based on their
physicochemical properties (see lab questions!) - ANSWER - Nonpolar, aliphatic R
groups:
Glycine, Alanine, Valine, Leucine, Methionine, Isoleucine
Polar, uncharged R groups:
Serine, Threonine, Cysteine, Proline, Asparagine, Glutamate

The benefits of buying summaries with Stuvia:

Guaranteed quality through customer reviews

Guaranteed quality through customer reviews

Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.

Quick and easy check-out

Quick and easy check-out

You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.

Focus on what matters

Focus on what matters

Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!

Frequently asked questions

What do I get when I buy this document?

You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.

Satisfaction guarantee: how does it work?

Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.

Who am I buying these notes from?

Stuvia is a marketplace, so you are not buying this document from us, but from seller conceptialresearchers. Stuvia facilitates payment to the seller.

Will I be stuck with a subscription?

No, you only buy these notes for $12.99. You're not tied to anything after your purchase.

Can Stuvia be trusted?

4.6 stars on Google & Trustpilot (+1000 reviews)

68175 documents were sold in the last 30 days

Founded in 2010, the go-to place to buy study notes for 15 years now

Start selling
$12.99
  • (0)
Add to cart
Added