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Psychopharmacology Drugs the Brain and Behavior 3rd Edition Meyer Nursing Test Bank
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Psychopharmacology Drugs the Brain and Behavior 3rd Edition Meyer Nursing Test Bank
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Psychopharmacology Drugs the Brain and Behavior 3rdEdition Meyer Nursing Test Bank
The absorption of a drug depends on all of the following except
A) Lipid solubility
B) Ionization
C) Body temperature
D) The concentration of the drug - Body temperature
Drugs administered _____ are absorbed the most rapidly - Intravenously
Most drugs and neurotransmitters act upon - Membrane-bound receptors
Biotransformation of drugs can result in the formation of _____, which enter the
circulation and cause _______. - Active metabolites; prolonged drug action
The primary "input zone" of the neuron is generally considered to be the - Dendrites
Inactivation of neurotransmitters can be accomplished by all of the following except for
A) Enzymatic breakdown in the synaptic cleft
B) transport back into the presynaptic cell
C) Transport into the postsynaptic cell
D) Transport into nearby glial cells. - Transport into the postsynaptic cell
In a myelinated axon, action potentials are regenerated - At gaps in the myelin known
as nodes of Ranvier
The absolute refractory period occurs because ______ channels cannot be opened,
and the relative refractory period occurs because __________ - Voltage gated Na+;
Voltage-gated K+ channels remain open
The specific effect of a particular neurotransmitter at a particular synapse is largely
determined by - The receptor subtype(s) present on the postsynaptic cell
Excitatory postsynaptic potentials are generally caused by _______ channels opening,
while inhibitory postsynaptic potentials may be caused by ______ channels opening. -
Na+; Cl-
After chronic use, the need to administer more of a drug to achieve the same drug effect
is known as - Tolerance
Repeated use of many psychoactive drugs can cause ____, which can speed up the
rate of biotransformation of these drugs as well as others - Enzyme induction
, In order for a drug to have an effect, it must first bind to a - Receptor
Ligand-gated ion channels are _______; G protein coupled receptors are _______. -
Fast/ionotropic; slow/metabotropic
Which of the following about drug clearance by first-order kinetics is FALSE?
A) Molecules of drug are cleared at a constant rate regardless of drug concentration
B) Molecules of drug are cleared at an exponential rate
C) A constant fraction of the free drug in the blood is removed in each time interval
D) Clearance of most drugs occurs in this manner - Molecules of drug are cleared at a
constant rate regardless of drug concentration
The ______ and ______ are components of the peripheral nervous system and relay
information about the interval and external environment, respectively. - Autonomic
nervous system; somatic nervous system
Which of the following statements about action potentials is FALSE?
A) They are considered all-or-none
B) Extreme excitation will result in a very large action potential
C) They move via salutatory conduction in myelinated axons
D) They are generated at the axon hillock - Extreme excitation will result in a very large
action potential
Activity at an axoaxonic synapse can directly increase the amount of neurotransmitter
released from the postsynaptic cell. This is known as - Presynaptic facilitation
The process of releasing neurotransmitter molecules from the vesicles is known as
_____ and occurs as a result of an influx of _____ - Exocytosis; Ca2+
Depot binding is said to occur when drugs - Bind to inactive sites
During the ____ period, no additional action potentials can be created - Absolute
refractory
Neural transmission is generally ____ within a single neuron and ____ between
neurons. - Electrical; chemical
The most common type of synapse in the brain is the ______ synapse - Axodendritic
Neurons rely on ____ for protection, metabolic support and insulation - Glial cells
Which of the following factors does NOT affect the pharmokinetics of a drug?
A) Route of Administration
B) Lipid solubility
C) Depot binding
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