WGU D116 Advanced Pharmacology for the Advanced Practice Nurse Exam | Study Questions and Answers | Latest 2024
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WGU D116
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WGU D116
WGU D116 Advanced Pharmacology for the Advanced Practice Nurse Exam | Study Questions and Answers | Latest 2024
WGU D116 Advanced Pharmacology for the Advanced Practice Nurse Exam | Study Questions and Answers | Latest 2024
WGU D116 Advanced Pharmacology for the
Advanced Practice Nurse Exam | Study
Questions and Answers | Latest 2024
What is the role of oral corticosteroids in the treatment of
rheumatoid arthritis?
YES Short-term therapy for flares in patients with established
disease
Disease-modifying antirheumatic drug (DMARD) monotherapy
Reducing adverse effects in patients taking methotrexate
Combination therapy during the first year of treatment with a
disease-modifying antirheumatic drugs (DMARD)
Correct! Corticosteroids are effective in the treatment of
rheumatoid arthritis by slowing the progression of erosions.
However, their long-term use in patients with rheumatoid arthritis
is limited by their breadth of adverse effects.
What is a recommended strategy for patients to do prior to
injecting disease-modifying antirheumatic drugs (DMARDs) to
decrease the pain of the injection?
Take an oral antihistamine 30 minutes before the injection
YES Allow the injection to come to room temperature
,Use a topical anesthetic
Take prednisone 5 mg 30 minutes before the injection
Correct! DMARDs are refrigerated and may cause discomfort
upon injection if they are not allowed to come to room
temperature.
Which traditional disease-modifying antirheumatic drug (DMARD)
may be the best option in a pregnant patient with rheumatoid
arthritis?
Cyclophosphamide
Leflunomide
YES Hydroxychloroquine
Methotrexate
Correct! Hydroxychloroquine is used in pregnancy and should be
monitored closely. Literature regarding human pregnancies and
hydroxychloroquine demonstrated no increase in the rate of birth
defects.
Which of the following is false about methotrexate?
YES Subcutaneous use requires folic acid replacement of 1 mg
per day.
If folic acid is needed to reduce side effects, a dose of 1 mg daily
,or 5 mg once weekly on the day following the methotrexate dose
is recommended.
Methotrexate may be used as monotherapy or in combination with
biologics.
Male and female patients should use contraception while using
methotrexate.
Correct! Folic acid replacement is used to reduce side effects of
methotrexate and is used orally and subcutaneously. Although
folic acid replacement is common and efficacious, its use is not
required.
For which antibiotic is time above the minimum inhibitory
concentration (MIC) most important?
Ciprofloxacin
NO Amikacin
NO Tobramycin
YES Cefpodoxime
Incorrect. Amikacin is an aminoglycoside. Time above the minimal
inhibitory concentration (MIC) is more important for time-
dependent antibiotics such as beta-lactams. The ratio of the peak
concentration to MIC and the area under the concentration-time
curve (AUC) to MIC are better clinical predictors of efficacy for
, concentration-dependent antibiotics such as aminoglycosides and
fluoroquinolones. Incorrect. Tobramycin is an aminoglycoside.
Time above the minimal inhibitory concentration (MIC) is more
important for time-dependent antibiotics such as beta-lactams.
The ratio of the peak concentration to MIC and the area under the
concentration-time curve (AUC) to MIC are better clinical
predictors of efficacy for concentration-dependent antibiotics such
as aminoglycosides and fluoroquinolones.
Correct! Cefpodoxime is a beta-lactam. Time above the minimal
inhibitory concentration (MIC) is more important for time-
dependent antibiotics such as beta-lactams. The ratio of the peak
concentration to MIC and the area under the concentration-time
curve (AUC) to MIC are better clinical predictors of efficacy for
concentration-dependent antibiotics such as aminoglycosides and
fluoroquinolones.
Procalcitonin levels can be useful in preventing antibiotic
misadventures.
YES True
False
Correct! Procalcitonin is a representative marker of bacterial
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