CMB2004 Questions and Answer | Latest Update 2024/2025
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Course
Cmb2004
Institution
Cmb2004
Why do we need immunological tolerance?
~~> This allows us to get random generation of the repertoire of BCR and
TCR
This means self-reactive specificities will be made
Without tolerance, we will get self destruction
How do lymphocytes become tolerant?
~~> Central tolerance - they enc...
~~> B cells get a second chance to rearrange any self-reactive BCR
They have further light chain gene rearrangement so that there is a possibility
of expressing a receptor that's not self-reactive
What happens to the immature T cells that fail the positive selection?
~~> They undergo further rearrangements of the TCR alpha locus to
produce a different receptor
What genes rearrange the receptors?
~~> RAG genes
What are anergic lymphocytes?
~~> The unresponsive lymphocytes that recognise self-antigens
How are immature B cells formed?
~~> When receptors encounter antigens that is not multivalent, this forms
immature B cells which downregulate BCR
How do T cells become anergic?
Master01 | September, 2024/2025 | Latest update
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