Solutions
2018 ACC/AHA Guideline on the Treatment of Blood
Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in
Adults
Groups Who Benefit From Statin Use: Correct Answers 1.
Patients with ASCVD
2. Patients with LDL ≥190 mg/dL
3. Patients with diabetes (no evidence of ASCVD), 40-75 years
old with LDL ≥70 mg/dL
4. Patients 40-75 years old without diabetes or ASCVD, but
LDL 70-189 mg/dL and elevated 10-year ASCVD risk:
7.5-20% risk or less (risk enhancers), start statin
5-7.5% risk (risk enhancers) and coronary artery calcium is zero
Statin can be deferred 5-10 years if nonsmoker, no family
history of premature ASCVD
Higher coronary artery calcium scores and/or 55 years or
younger, favor starting statin
A patient is immunized against Hep when Correct Answers
anti-HBs is positive
According to the 2018 ACC/AHA Guideline on the Treatment
of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular
Risk in Adults, ASCVD risk enhancers are: Correct Answers
Family history of premature ASCVD
Persistent elevation LDL ≥160 mg/dL
Chronic kidney disease
Metabolic syndrome
Preeclampsia, premature menopause
, Inflammatory disease (RA, psoriasis, HIV)
Ethnicity (e.g., South Asian heritage)
Persistent elevation of triglycerides ≥175 mg/dL
According to the 2018 ACC/AHA Guideline on the Treatment
of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular
Risk in Adults, what is the reduction goal for high-intensity
statin therapy? Correct Answers Goal: 50% reduction in LDL
with statin (atorvastatin 40-80 mg daily; rosuvastatin 20-40 mg
daily)
According to the 2018 ACC/AHA Guideline on the Treatment
of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular
Risk in Adults, what is the reduction goal for moderate-intensity
statin therapy? Correct Answers Goal: 30-50% reduction in
LDL with statin (atorvastatin 10 mg or 20 mg daily; fluvastatin
40 mg BID, 80 mg daily; lovastatin 40-80 mg daily; pitavastatin
1-4 mg daily; pravastatin 40-80 mg daily; rosuvastatin 5-10 mg
daily; simvastatin 20- 40 mg daily)
According to the 2018 ACC/AHA Guideline on the Treatment
of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular
Risk in Adults, when should high-intensity statin therapy begin?
Correct Answers Secondary prevention in adults >75 years
Primary prevention in adults 20-75 years with LDL ≥190 mg/dL
Primary prevention in adults 40-75 years with LDL 70-189
mg/dL PLUS estimated ASCVD risk of ≥20% and in some cases
≥7.5%
Primary prevention in diabetes patients 40-75 years with LDL
70-189 mg/dL and multiple risk factors