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NURS 5220 Exam Practice Questions and Answers | 100% Pass

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NURS 5220 Exam Practice Questions and Answers | 100% Pass What are benzodiazepines? - Answer️️ -A class of drugs used for anxiety and other purposes. What are the uses of benzodiazepines? - Answer️️ -Sedation, hypnosis, muscle relaxation, anxiolysis, anticonvulsant, amnesia, insomnia, ...

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  • September 16, 2024
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NURS 5220 Exam Practice Questions
and Answers | 100% Pass


What are benzodiazepines? - Answer✔️✔️-A class of drugs used for anxiety and other

purposes.


What are the uses of benzodiazepines? - Answer✔️✔️-Sedation, hypnosis, muscle

relaxation, anxiolysis, anticonvulsant, amnesia, insomnia, alcohol withdrawal.

What is the structure of benzodiazepines? - Answer✔️✔️-Benzodiazepine ring with 2

nitrogen atoms at positions 1 & 4, phenyl group at position 5, and an electronegative

group at position 7.

How do benzodiazepines work? - Answer✔️✔️-They promote the binding of GABA to the

GABAA receptor, enhancing GABA-induced chloride currents and inhibiting neuronal

cell excitation.

How are benzodiazepines metabolized? - Answer✔️✔️-They are oxidized in the liver via

CYP enzymes, primarily CYP3A4.

What are the active metabolites of benzodiazepines? - Answer✔️✔️-Diazepam (with a

half-life exceeding 100 hours) and midazolam (rapidly metabolized to an α-hydroxylated

compound with biologic activity).

Which benzodiazepines have no active metabolites? - Answer✔️✔️-Oxazepam,

lorazepam, and temazepam.



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, ©SOPHIABENNETT 2024/2025 9:45 AM


What factors can alter the metabolism of benzodiazepines? - Answer✔️✔️-Disease and

age.

What is the duration of action of benzodiazepines primarily determined by? -

Answer✔️✔️-The α phase (distribution-redistribution from CNS) dynamics rather than the

rate of elimination.

What are the pharmacodynamic effects of benzodiazepines on the CNS? - Answer✔️✔️-

CNS depressant effects including anxiolysis, sedation, sleep, anticonvulsant, amnesia,

muscle relaxation, and inhibition of alcohol withdrawal symptoms.

What effect do high doses of benzodiazepines have on CMR02 & CBF? - Answer✔️✔️-

They reduce CMR02 & CBF.

What effect do benzodiazepines have on the threshold to local anesthetic-induced

seizures? - Answer✔️✔️-They increase the threshold to local anesthetic-induced

seizures.

What is the dose-related effect of benzodiazepines on anterograde amnesia? -

Answer✔️✔️-They cause anterograde amnesia at high doses.

What are the potential drawbacks of benzodiazepine use? - Answer✔️✔️-Awareness

regarding addiction, withdrawal, recreational abuse, and the development of other drug

classes has led to a decline in their use.

Which CYP enzyme is primarily responsible for the metabolism of benzodiazepines? -

Answer✔️✔️-CYP3A4.

Which benzodiazepine has a half-life exceeding 100 hours? - Answer✔️✔️-Diazepam.




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