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MCMP 422 Exam 3 Questions And Accurate Answers
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MCMP 422 Exam 3 Questions And Accurate Answers"Original antigenic sin" is best defined as a phenomenon wherein ___.
A. highly mutable virus progressively escapes the immunologic memory and
compromises compensatory immune responses.
B. latent viruses episodically reactivate T effector cells that are specific to the originally
recognized antigen presented in the primary immune response.
C. antigen persistence is required to maintain immunologic memory.
D. memory T cells no longer express the same profile of adhesion molecules and
cytokine receptors compared with the original profile of the naive precursor T cell. -
Answer A. a highly mutable virus gradually escapes from immunological memory and
interferes with compensatory immune responses.
A conjugate vaccine is one that couples _____ to _____ so as to stimulate T-dependent
antibody responses.
A. polysaccharide; a protein carrier
B. a protein carrier; irradiated DNA
C. protein carrier; toxoids
D. adjuvant; toxoids
E. ysaccharide; filamentous hemagglutinin - Answer A. polysaccharide; a protein carrier
An adjuvant enhances the effectiveness of vaccines through the induction of the
expression of _____ on ________.
A.co-stimulatory molecules; macrophages and dendritic cells
B. CD28; macrophages
,C. MHC class II molecules; T cells
D. T-cell receptor; T cells
E. immunoreceptor tyrosine-based activation motifs; dendritic cells - Answer A.
co-stimulatory molecules; macrophages and dendritic cells
What is the mechanism by which fetal erythrocytes are destroyed in hemolytic anemia of
the newborn?
A. lysis of erythrocytes by cytotoxic T cells
B. lysis of erythrocytes by complement activation
C. clearance of antibody-coated erythrocytes by macrophages in the fetal spleen
D. lysis of erythrocytes by NK cells via antibody-dependent cell-mediated cytotoxicity
E. cytotoxicity due to major basic protein released from eosinophils. - Answer C.
removal of antibody-coated erythrocytes by macrophages in the fetal spleen
By what means do memory B cells involved in a secondary immune response differ from
the naive B-cell population activated in a primary immune response? (Select all that
apply.)
A. The antibody produced is of higher affinity in a secondary immune response.
B. Antigen-specific B cells are in low frequency in a secondary immune response.
C. Somatic hypermutation is more extensive in the secondary immune response.
D. IgM is produced in greater quantity in the case of secondary immune responses.
E. The T-cell help is not required for B cells in the case of secondary immune responses.
F. Memory B cells express a higher amount of MHC class II molecules.
G. Naive B cells express higher levels of co-stimulatory molecules. -Answer A. The
antibody produced is of higher affinity in a secondary immune response.
C. The level of somatic hypermutation is higher in a secondary immune response.
F. Memory B cells express higher levels of MHC class II molecules.
,Memory B cells differ from memory T cells in the following ways. Choose all that apply.
A. They inactivate naive antigen-specific lymphocytes during the secondary immune
responses.
B. They recirculate only through the secondary lymphoid organs.
C. They secrete their antigen receptors throughout their life-span.
D. That during the primary immune response, they develop long-lived clones of memory
cells. -Answer A. They inactivate naive antigen-specific lymphocytes during the
secondary immune responses.
B. They recirculate only through the secondary lymphoid organs.
CD45RA isoform is associated with stronger signals in response to antigen.
A. True
B. False - Answer B. False
The vaccine against Human Papilloma Virus (HPV) is considered controversial for what
association?
A. the implicit association with adolescent sexual activity
B. association with higher rates of cervical cancer
C. low levels of efficacy in eliminating HPV
D. high rates of side effects - Answer A. the implicit association with adolescent sexual
activity
Viruses for vaccine use are inactivated by ____.
A. irradiation
B. heat treatment
C. mutation
, D. formalin treatment - Answer A. irradiation
B. heat treatment
D. formalin treatment
Which of the following is characteristic of immunological memory? (Select all that
apply.)
A. The host retains the ability to initiate a secondary immune response.
A. The host retains the capacity to mount a secondary immune response.
B. The host retains the ability to respond to pathogen many years after primary
exposure.
C. Naive T cells are activated more quickly when exposed to pathogen.
D. Memory B cells produce higher-affinity antibody than naive B cells.
E. Memory T cells undergo somatic hypermutation.
F. Memory T cells express CD45RA. Answer A is the correct definition of immunologic
memory.
B. The host retains the capability to respond to pathogen many years after primary
exposure.
D. Memory B cells make higher-affinity antibody compared to naive B cells.
Which of the following is NOT true about an inactivated or killed virus vaccine?
A. It induces a robust B cell response
B. It induces a robust T cell response
C. Is generally administered intramuscularly
D. It usually results in a humoral response - Answer B. It results in an intense T cell
response
The following statements listed below are not true about memory B cells. Which one?
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