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COUN 6743 PSYCHOPHARMACOLOGY FINAL EXAM 2024/2025 VERIFIED QUESTIONS AND ANSWERS GRADED A+
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COUN 6743 PSYCHOPHARMACOLOGY FINAL EXAM 2024/2025 VERIFIED QUESTIONS AND ANSWERS GRADED A+
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COUN 6743 PSYCHOPHARMACOLOGYCOUN 6743 PSYCHOPHARMACOLOGY FINAL
EXAM 2024/2025 VERIFIED QUESTIONS AND
ANSWERS GRADED A+
A 49-year-old clerk with bipolar disorder has been maintained on 900mg/ day of
lithium. She was doing well for a long time and had even been able to lose the
weight she initially gained with lithium. She broke up with her boyfriend five
months ago and has been feeling depressed ever since. You augment her with
300mg / day of quetiapine but after a few weeks she complains of weight gain and
wants to change medications. Blockade of which two receptors was most likely
responsible for this weight gain induced by quetiapine?
Select one:
a. Serotonin 2A and muscarinic 3
b. Dopamine 2 and alpha 1 adrenergic
c. Muscarinic 1 and serotonin1A
d. Serotonin 2C and histamine 1
D. Serotonin 2C and histamine 1
-Blockade of serotonin 2C and histamine 1 receptors has been linked to weight
gain.
The 'bipolar storm' refers to the concept that unstable, unregulated, and excessive
neurotransmission occurs at synapses in specific brain regions, and both voltage-
,COUN 6743 PSYCHOPHARMACOLOGY
sensitive sodium channels and voltage-sensitive calcium channels are involved in
this excessive stimulation of glutamate release. Which drugs would theoretically
reduce glutamate release by blocking voltage-sensitive sodium channels?
Select one:
a. Valproate and lamotigine
b. Pregabalin and gabapentin
c. Leveritracetam and amantadine
d. Lamotrigine and quetiapine
a. Valproate and lamotigine
-Valproate and lamotrigine both affect the voltage sensitive sodium channels
hypothesized to reduce glutamate release.
We have an expert-written solution to this problem!
You have diagnosed a 23 year-old college student with rapid cycling bipolar
disorder and elect to start her on depakote 1500mg / day. Prior to initiating the
medication what lab screening is recommended?
Select one:
a. CBC / platelets, LFT, serum amylase, and pregnancy
b. CBC / neutrophils, FLP, serum amylase
c. CBC / platelets, FLP, serum amylase and pregnancy
,COUN 6743 PSYCHOPHARMACOLOGY
d. CBC, BMP, sodium levels, and pregnancy
Question 4
a. CBC / platelets, LFT, serum amylase, and pregnancy
-Recommended screening prior to initiating valproate is CBC/platelets, LFT,
serum amylase, and pregnancy (if female).
Ten-year-old Rebecca experienced seizures as a toddler. Her mother took her to a
psychiatrist at age eight, because she had violent outbursts of anger, was attacking
her older brother, and was severely irritable. That behavior had been going on for
the over six months. After screening for ADHD and conduct disorders, the
provider diagnosed her with bipolar I disorder and put her on 800 mg / day of
carbamazepine. Over the last few years she has only had a couple of manic
episodes but has recently started to have debilitating migraines. She has gained
weight as well, and her BMI is 30. Her mother does not want her to be put on any
medication that could lead to more weight gain. Which medication and dose could
be added to her current treatment?
Select one:
a. Topiramate at 150mg a day
b. Topiramate at 400mg a day
c. Lithium at 1800mg a day
d. Olanzapine at 30mg a day
a. Topiramate at 150mg a day
, COUN 6743 PSYCHOPHARMACOLOGY
-While we might wonder at a bipolar I diagnosis at age 8 and the use of
carbamazapine, in this case study the most appropriate answer is topiramate at
150mg/day, which is being used off label as an adjunct for bipolar disorder but is
FDA approved for treatment of migraine, and which might even lead to weight
loss. The dose of 150mg a day is appropriate for pediatric use.
James, a 32-year-old marine biologist, was diagnosed with bipolar disorder at the
age of 18. He has been maintained on 900mg / day of lithium and 100mg / day of
lamotrigine. He recently had his wisdom teeth removed and has been taking 600mg
of ibuprofen 2 - 3 times a day. He suddenly experiences tremor, diarrhea, vomiting,
and extreme sedation. What could be the cause of these side effects?
Select one:
a. Lamotrigine increases the plasma levels of ibuprofen leading to ibuprofen
toxicity
b. Ibuprofen increases the plasma levels of lithium leading to lithium toxicity
c. Lithium increases the plasma levels of lamotrigine leading to lamotrigine
toxicity
d. He is experiencing an infection due to the removal of his wisdom teeth
b. Ibuprofen increases the plasma levels of lithium leading to lithium toxicity
-NSAIDS such as ibuprofen can increase plasma lithium concentrations by
interfering with the renal elimination of lithium, leading to lithium toxicity
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