NU 545 ADVANCE PATHOPHYSIOLOGY UNIT 2 EXAM- UNIVERSITY OF SOUTH ALABAMA | COMPLETE SOLUTION| 2024
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Course
University Of South Alabama.
Institution
University Of South Alabama.
NU 545 ADVANCE PATHOPHYSIOLOGY UNIT 2 EXAM- UNIVERSITY OF SOUTH ALABAMA | COMPLETE SOLUTION| 2024
Afferent - Towards (towards the spinal cord)
Efferent - Away From (away from the spinal cord)
Which nerves are incapable of regeneration? - Neurons in the Central Nervous System (CN...
Which nerves are incapable of regeneration? - Neurons in the Central Nervous System
(CNS) do not divide and injury causes permanent loss.
Which injury to nerves has better outcomes? Crushed or Severed/Cut - Crushed
nerves recover better
How do peripheral nerves repair themselves? - Axonal Reaction
Name 8 local changes that occur when an axon is severed - 1. Cut end retracts and the
axolemma covers the cut end, reducing escape of axoplasm
2. macrophages and Schwann cells begin to phagocytize damaged tissue
3. Cell body undergoes chromotolysis, loss of Nissl bodies, and lateral migration of
nucleus
4. Antegrade (wallerian) degeneration occurs in the distal axon
5. Swelling in axon terminal, it degenerates and loses contact with post synaptic
membrane within 7 days
6. Macrophages and Schwann cells phagocytize remnants of axon terminal
7. Schwann cells proliferate, forming a column or tube of schwann cells enclosed by the
original basal lamina of the endoneurium
8. Retrograde changes occur at the promixal end of the injured axon and are similar to
antegrade changes but only back to the next node of Ranvier
Retrograde changes to the Proximal end of an injured axon only go back to what? -
The next node of Ranvier
In what time span do new terminal sprouts project from the proximal segment of an
injured axon? - 7-14 days
What is the length of growth per day of an injured axon? And what is regrowth limited
to? - 1mm/day. Limited to myelinated fibers in the Peripheral Nervous System (PNS)
, The closer the injury is to the cell body of a nerve... - The greater the chances that the
cell will die and not regenerate
How does the location of an injury among Peripheral Nerves play a factor? - Injured
nerves closer to the spinal cord recover slower and poorly because of the long distance
between the cell body and the peripheral termination of the axon.
Regeneration of axonal constituents in the CNS is limited by what - glial scar formation
(gliosis) and the different nature of myelin formed by the oligodendrocyte
What 4 factors do nerve regeneration depend on - 1. Location of injury
2. Type of injury (crushing vs cut)
3. Presence of inflammatory responses
4. Process of scarring
Weight of Brain and amount of cardiac output received - 3lbs and 15-20% of cardiac
output
Prefrontal Area is responsible for what? - Goal-oriented behavior, short term memory,
concentration, elaboration of thought and inhibition of limbic area. (emotions)
Premotor area (Brodmann area 6 ) is responsible for what? - motor movement,
extrapyramidal system, eye movement, (Brodmann area 8, middle frontal gyrus)
Primary motor area is responsible for what? - Primary voluntary motor = somatotropic
organization (Homunculus = little man)
Cerebral cortex controls central impulses for the opposite side of the body.
Control of the opposite side of the body is called what? - Contralateral control
Broca's speech area (Brodmann area 34, 45) is responsible for? - Motor aspect of
speech. Speech and language processing, Dysfunction can result in inability to form
words. "Expressive aphasia"
Somatic sensory input (Brodmann area 3,1,2) is responsible for? - Provides
communication between motor and sensory areas, storage, analysis, and interpretation
of stimulus
Wernicke area (Brodmann 22) is responsible for? - Sensory speech area: responsible
fro reception and interpretation of speech (superior temporal gyrus) dysfunction may
result in receptive aphasia or dysphasia
Primary visual cortex (brodmann area 17) is responsible for what? - Receives input
from the retinas
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