TRANSDERMAL DRUG DELIVERY, TABLETS,
MODIFIED RELEASE ORAL DOSAGE FORMS,
LIQUID DOSAGE FORMS EXAM QUESTIONS
AND ANSWERS
Transdermal drug delivery - ✔✔ANSWER✔✔-Supports
drug passage from skin surface to systemic circulation
, Transcellular pathway - ✔✔ANSWER✔✔-Direct passage
through phospholipid membranes and cytoplasm of
keratinocytes
Intercellular pathway - ✔✔ANSWER✔✔-Drugs move
through extracellular spaces, reducing rate of penetration
Trans-appendageal pathway - ✔✔ANSWER✔✔-Polar
molecules penetrate through pores of hair follicles and
sebaceous glands
Passive diffusion - ✔✔ANSWER✔✔-High concentration to
low concentration movement of drugs
Properties of drug candidates for transdermal delivery
systems - ✔✔ANSWER✔✔-Aqueous and lipid soluble
substances, low molecular weight, favorable partition
coefficient, modest melting point
Permeability enhancers - ✔✔ANSWER✔✔-Substances
like DMSO, ethanol, propylene glycol, and surfactants
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