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NURS8024 Pharm Exam 1 Questions and Answers 100% CorrectNURS8024 Pharm Exam 1 Questions and Answers 100% CorrectNURS8024 Pharm Exam 1 Questions and Answers 100% CorrectNURS8024 Pharm Exam 1 Questions and Answers 100% Correct Gastric acid secretion by parietal cells of the gastric mucosa are stimul...

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  • September 16, 2024
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  • nurs8024 pharm exam 1 questions and answers 100 c
  • nurs8024 pharm exam 1 questions and answers stuvia
  • gastric acid secretion by parietal cells of the ga

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NURS8024 Pharm Exam 1
Questions and Answers 100%
Correct
Gastric acid secretion by parietal cells of the gastric mucosa are stimulated by -
ANSWER - *acetycholine, histamine, gastrin


Receptor-mediated binding of acetylcholine, histamine, or gastrin results in -
ANSWER - *the activation of protein kinases, which in
turn stimulates the H+/K+-adenosine triphosphatase (ATPase) proton pump


Gastrin and acetylcholine stimulate release of - ANSWER - histamine


receptor binding of prostaglandin E2 and
somatostatin diminish - ANSWER - gastric acid production


Antacids - ANSWER - weak bases that react with gastric acid to
form water and a salt → diminishing gastric acidity


Reduce pepsin activity - pepsin inactive at a pH >4


Wide variety* in chemical composition, acid-neutralizing capacity, sodium content,
palatability, and price


Acid neutralizing ability* of an antacid depends on its capacity to neutralize gastric
HCl and on whether the stomach is full or empty
• food delays stomach emptying, allowing more time for the antacid to react


Therapeutic uses of antacids - ANSWER - • Symptomatic relief of peptic ulcer
disease (PUD) and gastroesophageal reflux (GERD)

,• May promote healing of duodenal ulcers, but not
robust evidence for efficacy in Tx of acute gastric
ulcers
• Calcium carbonate preparations
• also used as calcium supplements for the treatment of osteoporosis


Commonly used antacid drugs - ANSWER - Classes
• Calcium salts: calcium carbonate: Tums/Rolaids
• Sodium bicarbonate: Alka-Seltzer
• Aluminum salts - Aluminum hydroxide: Amphojel; Aluminum carbonate: Basaljel
• Magnesium salts/ magnesium oxide: Milk of Magnesia
• Combination products
• Aluminum hydroxide and magnesium hydroxide (Maalox, Mylanta)
• Alginic acid, magnesium trisilicate, calcium stearate
(Gaviscon)


Adverse effects of antacids - ANSWER - • Aluminum hydroxide tends to be
constipating
• Magnesium hydroxide tends to cause diarrhea
• Binding of phosphate by aluminum-containing antacids → hypophosphatemia
• Sodium bicarbonate → belching and flatulence, potential for systemic alkalosis
• Sodium content of antacids → can be important in pts w/ HTN or CHF
• Excessive intake of calcium carbonate along w/ calcium foods → hypercalcemia


Mucosal Protective Agents - ANSWER - Cytoprotective compounds
Sucralfate
Bismuth Compounds


Cytoprotective Compounds - ANSWER - enhance mucosal protection

,mechanisms → preventing mucosal injury, ↓ inflammation, promotes healing of
existing ulcers


Sucralfate - ANSWER - complex of aluminum hydroxide and sulfated sucrose
• Small, poorly soluble molecule
• Polymerizes in stomach acid → binds to injured tissue, forms physical barrier
coating over ulcer bed- impairs diffusion of HCl and prevents degradation of mucus
by pepsin and acid
• Accelerates healing of peptic ulcers and ↓ recurrence rate
• Stimulates prostaglandin release, mucus and bicarbonate output
• *BIG drawback.... Must be taken qid• used in long-term maintenance therapy to
prevent recurrence
• Requires an acidic pH for activation -should not be administered with H2
antagonists or antacids
• Little of the drug is absorbed systemically, very well tolerated
• Can interfere w/ absorption of other drugs by binding to them
• Does not prevent NSAID-induced ulcers


Antisecretory agents - ANSWER - Histamine-2 receptor antagonists
Proton pump inhibitors


Examples of Histamine-2 receptor antagonists - ANSWER - ranitidine, *cimetidine,
famotidine, nizatidine


Examples of Proton pump inhibitors - ANSWER - • omeprazole, esomeprazole
• Lansoprazole, pantoprazole
• rabeprazole


Bismuth Compounds - ANSWER - • Coats ulcers → protective layer against acid and
pepsin
• May stimulate prostaglandin, mucus, and bicarbonate secretion
• Antimicrobial effect- binds enterotoxins

, • reduces stool frequency & liquidity in acute infectious diarrhea
• Causes black stools- harmless
• Avoid in renal insufficiency


In geriatric patients avoid use of - ANSWER - - antacids that contain magnesium in
patients with renal failure
- sodium-containing antacids because of fluid
retention


Antacids in Pediatrics - ANSWER - Safety not established in children


Antacids during pregnancy and lactation - ANSWER - No FDA category established,
although antacids
generally are considered safe for use in pregnancy




H2 Receptor antagonists - ANSWER - • MOA
• Acts selectively on H2 receptors in the stomach, blood vessels, and other sites (no
effect on H1 receptors)
• Competitively blocks binding of histamine to H2 receptors
• less effective than PPIs against stimulated secretion
• Four drugs: cimetidine*. ranitidine, famotidine, and nizatidine
• Can inhibit > 90% basal, food-stimulated and nocturnal secretion of gastric acid
after a single dose
• Main clinical use is to inhibit gastric acid secretion
• particularly effective against nocturnal acid secretion


H2 Receptor antagonist ADEs - ANSWER - • H2 antagonists very safe
• ADE < 3% of patients - diarrhea, h/a, fatigue, myalgias, constipation
• Drugs such as ketoconazole, which depend on an acidic medium for gastric
absorption, may not be efficiently absorbed if taken w/ H2 blocker

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