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NURS 8024 Pharm Exam 3 (antimicrobial part 2) Revision Exam Questions With Correct Complete Solutions. $9.99   Add to cart

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NURS 8024 Pharm Exam 3 (antimicrobial part 2) Revision Exam Questions With Correct Complete Solutions.

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  • NURS 8024
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  • NURS 8024

Bacterial protein synthesis inhibitors - Answer Clindamycin Clindamycin - Answer Time dependent killing Inhibits protein synthesis Bacteriostatic 90% bioavailability Clindamycin mechanism of resistance - Answer Altered target sites Active efflux (pushes drug out of the cell) ...

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  • September 17, 2024
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  • NURS 8024
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NURS 8024 Pharm Exam 3 (antimicrobial
part 2) Revision Exam Questions With
Correct Complete Solutions.
Bacterial protein synthesis inhibitors - Answer Clindamycin



Clindamycin - Answer Time dependent killing

Inhibits protein synthesis

Bacteriostatic

90% bioavailability



Clindamycin mechanism of resistance - Answer Altered target sites

Active efflux (pushes drug out of the cell)



Clindamycin ADE - Answer GI upset

Skin rash

Neutropenia

Superinfections such a c diff pseudomembranous

- don't use if patient has history of c diff



Clindamycin indications - Answer Gram positive

Prophylaxis of endocarditis in valve patients with PCN allergy



Oxazolidinones - Answer New class of bacterial protein synthesis inhibitors



Time dependent killing

Prevents formation of ribosome complex

, Bacteriostatic & Bactericidal against strep



Linezolid - Answer Protein synthesis inhibitor

100% bioavailability orally

30% CSF penetration



Linezolid ADE - Answer Hematologic

Increased thrombocytopenia risk

Anemia, neutropenia, neuropathy

Optic & peripheral neuropathy

Serotonin syndrome with SSRIs



Linezolid Indications - Answer Gram positive resistant

VRE, HCAP, CAP

Complicated skin & tissue infections

Off label use for TB

No resistance currently



Fluoroquinolones - Answer Norfloxacin (1st gen)

Ciprofloxacin & Ofloxacin (2nd gen)

Levofloxacin (3rd gen)

Moxifloxacin & Gemifloxacin (3rd gen respiratory)



Fluoroquinolones are classified by - Answer Generations according to antimicrobial spectra



1st Generation Fluoroquinolone - Answer Narrow gram negative

Norfloxacin



2nd Generation Fluoroquinolone - Answer Broad- gram negative and gram positive

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