, ADVANCED PATHOPHYSIOLOGY UTMB 5355 EXAM 3 /UTMB5355
Exam 3 QUESTIONS AND VERIFIED ANSWERS 2023/2024 LATEST
GUIDE
1. Biogenic Amine Theory linked to depression: Deficiency of neurotransmittersin brain of
norepinephrine, dopamine, and/or serotonin. Particularly, a decrease in receptor binding with serotonin.
2. Neurotransmitter Receptor Hypothesis linked to depression: A deficiency ofmonoamine
neurotransmitters at neuronal synapses.
3. Antidepressants increase: Neuronal synaptic levels of monoamine neurotrans-mitters.
4. if you have more receptors than neurotransmitters: Neurotransmitters do nothave time to re-
charge thus, they do not function properly.
5. Hypothalamic-Pituitary-Adrenal (HPA) System Dysregulation: HPA system dysregulation with
excessive glucocorticoid secretion is found in a large percentageof people suffering from major
depression.
6. Patho of Alzheimer's includes - plaque formation, presence of --, with de- creased levels of -:
Amyloid B, neurofibrillary tangles, acetylcholine these disruptimpulse transmission
7. neurofibrillary tangles: are a deformation of the structure that carries nutrientsto neurons of the
brain.
8. Decreased levels of choline acetyl transferase and acetylcholine is associ-ated with: Memory
loss
9. Most common cause of dementia: Alzheimer's disease fatal 5-10 years
10. Characteristics of Alzheimer's: Loss of memory, language , inability to learn new things,
dysfunction, delusions, cannot perform ADLs, majorly effects social life
11. Parkinson's Disease is: Chronic motor progressive neuro-degenerative knownas a shaking palsy
12. Parkinson's disease is associated with: basal ganglia dysfunction and atro-phy of neurons in the
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