Phcy 401 – ADME Exam Study Guide.
Pharmacokinetics - answerstudy of movement of drugs in body
absorption - answermovement of drug from application site to blood stream
distribution - answermovement of drug from blood stream to target
metabolism - answertransformation, activation, detox of dru...
properity of memb to allow passage of molecules - answer✔leakiness
if a molecule has low h2o solubility -- it has ____ lipophilicity allowing passage across memb -
answer✔high
leaky membranes transport are _______ of lipophilicty, charge, and molecular size -
answer✔independent
well knit membrane transport is _____ by lipophilicty, charge, and molecular size -
answer✔affected
tight knit memb transport is _______ ________ on lipophilicity, charge, and molecular size -
answer✔highly dependent
2 main active transporter families - answer✔ATP binding cassette (ABC)
solute carrier (SLC)
solute carriers (SLC) - answer✔facilitative / secondary active transporter
influx
routes of administration by level of absorption - answer✔IV
inhalation
IM
oral
dermal
physiologic factors influencing drug absorption (4) - answer✔blood flow
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