PMCOL 200 – Psychosis Exam Questions With Correct Answers
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Course
Pmcol 200
Institution
Pmcol 200
PMCOL 200 – Psychosis Exam Questions
With Correct Answers
Psychotic disorders - answera range of mental disorders that all involve symptoms of
psychosis
Psychosis - answerloss of contact with reality, affecting a persons ability to think, feel, and
act.
Most people with psychosis are aware ...
What are the 3 biochemical theories of schizophrenia? - answer✔1 - Dopamine Hypothesis
(excess)
2 - Reduced serotonin
3 - Reduced glutamate or GABA
What support do we have for the dopamine hypothesis? - answer✔Psychotic symptoms can be
developed by drugs that stimulate DA activity in non-schizophrenic persons.
Psychotic symptoms can be decreased with drugs that block DA receptors.
What drugs typically work by blocking 5HT receptors - answer✔SGAs: Second Generation
Antipsychotic drugs (atypical)
What support do we have for the reduced serotonin hypothesis? - answer✔Hallucinogens such
as lysergic acid (LSD) are 5-HT2 agonists.
What support do we have for the reduced glutamate or GABA hypothesis? -
answer✔Phencyclidine (PCP), a potent glutamate receptor inhibitor, can mimic not only the
positive, but also the negative symptoms of schizophrenia.
What three brain systems does dopamine act on? - answer✔1 - Mesolimbic/Mesocortical
2 - Tuberoinfundibular
3 - Nigrostriatal System
What does the Mesolimbic/Mesocortical system do? What happens if it is disturbed? -
answer✔memory, learning, affect, and thought organization.
Disturbances in this pathway contribute to psychotic symptoms
What does the Tuberoinfundibular system do? - answer✔secretion of some pituitary hormones,
particularly prolactin and growth hormone.
What does the Nigrostriatal System do? - answer✔Involved in tardive dyskinesis and the
Parkinson-like side effects seen after chronic use of antipsychotic drugs.
What happens in the mesolimbic/mesocortical pathway in untreated schizophrenia? -
answer✔The mesolimbic/mesocortical pathway is overactive and produces an excess amount of
dopamine
What happens in the mesolimbic/mesocortical pathway in treated schizophrenia? - answer✔The
postsynaptic DA receptors are blocked, and even though there is still overproduction, there are
no symptoms of schizophrenia
What are the 2 main types of DA receptors? - answer✔1 - D1 - stimulates adenylate cyclase
(Gs)
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