PMCOL 344 Hematopoietic Exam Questions
With Correct Answers
Hydroxocobalamin - answer✔Vitamin B12 therapy to treat anemia
Darbopoietin - answer✔Hyper-glycosylated form of Epo (recombinant human erythropoietin),
longer half-life than others
CERA - answer✔Continuous erythropoietin receptor activation -> post-translationally modified
epoietin beta, linked to polyethylene glycol which prolongs its half-life to 6 days.
Recombinant Epo fusion proteins - answer✔Epo (peptide) fused to Fc portion of human IgG ->
administered by inhalation
Epo mimetic peptides (EMPs) - answer✔Small cyclic synthetic products (~20 aa) linked to
polyethylene glycol - possible CV risk
Acetyl salicylic acid - answer✔Irreversibly iTinhibits COX1+2, preventing formation of
TXA2, decreasing platelet aggregation but has several side effects. NSAID.
Ticlopidine - answer✔Thienopyridine -> orally active prodrug that requires hepatic metabolism
(CYP2C19) to be activated. Irreversible antagonists of ADP binding site on P2Y12 receptors
(which usually promote platelet aggregation). Can cause neutropenia and thrombocytopenia.
Clopidogrel - answer✔Thienopyridine -> orally active prodrug that requires hepatic
metabolism (CYP2C19) to be activated. Irreversible antagonists of ADP binding site on P2Y12
receptors (which usually promote platelet aggregation). Fewer serious effects than others and
usually used by ASA intolerant individuals.
Prasugrel - answer✔Thienopyridine -> orally active prodrug that requires hepatic metabolism
(CYP2C19) to be activated. Irreversible antagonists of ADP binding site on P2Y12 receptors
(which usually promote platelet aggregation). Fastest biotransformation to active metabolite so
more efficatious (but also more risk of bleeding)
Ticagrelor - answer✔Reversible allosteric P2Y12 antagonist, NOT a thienopyridine, not a pro-
drug. Side effects include dyspnea and bradyarrhythmia.
Dual anti-platelet therapy (DAPT) - answer✔ASA and clopidogrel OR ticagrelor, up to one
year following MI and one month following cerebrovascular stroke
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