Lecture 10 PMCOL 371 Exam Study Guide.
Size of recpetors for ligand gated ion channels - answerlarge, multisubunit proteins
speed of ligand gated ion channels - answervery fast (can be submillisecond)
type of agonists - answersmall molecules
do receptors desensitize? - answeryes after continued...
Size of recpetors for ligand gated ion channels - answer✔large, multisubunit proteins
speed of ligand gated ion channels - answer✔very fast (can be submillisecond)
type of agonists - answer✔small molecules
do receptors desensitize? - answer✔yes after continued presence
weak presynaptic depolarization effect on presynaptic calcium current - answer✔gradual
increase in curren
small tail currrent
strong depolarization effect on presynaptic calcium current - answer✔no change in current
during depolarization (Vm > ECa)
large tail current causing short large conductance Ca influx
weak presynaptic depolarization effect on postsynaptic potential - answer✔gradually lets
calcium to trigger NT release with delay between presynaptic step and EPSP
strong depolarization effect on postsynaptic potential - answer✔onset of opening/depol from
repolarizing step is very quick
what channel is abundant in electrical organs of the torpedo fish - answer✔nicotinic
acetycholine receptor (nAChR)
what blocks nAChR - answer✔d-tubocurarine and alpha-bungarotoxin
structural properties of nAChR - answer✔pentamer of 4 homologous subunits - 2 alpha, 1 beta,
1 gamma, one delta
whats special about the 2 alpha subunits - answer✔carry a part of the binding sites for alpha-
bungarotoxin and ACh
homologous neuronal nAChRs - answer✔stochiometry alphan betan?
blocked by K-bungarotoxin
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