PHARMACOLOGY 14TH EDITION KATZUNG TREVOR TEST BANK COMPLETE TEST BANK ALL QUESTIONS WITH SOLUTIONS
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Course
PHARMACOLOGY 14TH EDITION KATZUNG TREVOR
Institution
PHARMACOLOGY 14TH EDITION KATZUNG TREVOR
PHARMACOLOGY 14TH EDITION
KATZUNG TREVOR TEST BANK
COMPLETE TEST BANK ALL QUESTIONS
WITH SOLUTIONSPHARMACOLOGY 14TH EDITION
KATZUNG TREVOR TEST BANK
COMPLETE TEST BANK ALL QUESTIONS
WITH SOLUTIONSPHARMACOLOGY 14TH EDITION
KATZUNG TREVOR TEST BANK
COMPLETE TEST BANK ALL QUESTIONS
W...
PHARMACOLOGY 14TH EDITION
KATZUNG TREVOR TEST BANK
COMPLETE TEST BANK ALL QUESTIONS
WITH SOLUTIONS
A soldiers' unit has come under attack with a nerve agent. The symptoms
exhibited are skeletal muscle paralysis, profuse brachial secretions, miosis,
bradycardia, and convulsions. The alarm indicates exposure to an
organophosphate. What is the correct treatment? - ANSWER>>administer
atropine and 2-PAM (pralidoxime)
The pKa (for the COOH group) of each of the three drugs is as follows: thyroxine
= 3.0, mesothyroxine = 4.0, neothyroxine = 5.0. Of these, which will be absorbed
to the greatest extent from the stomach (pH = 1.0)? - ANSWER>>neothyroxine
The multi drug resistance proteins (or p-glycoproteins) can protect liver and
kidney cells by exporting harmful chemicals against a concentration gradient in
an energy-dependent manner. What is this called? - ANSWER>>active transport
Phase II conjugates typically have the following property/properties -
ANSWER>>rapidly excreted in the urine
,A drug with a half-life of 2 hours is administered by continuous intravenous
infusion. How long will it take for the drug to reach 50% of its steady state
concentration? - ANSWER>>2 hours
Caffeine is eliminated primarily by metabolism and with first order kinetics. The
half-life of caffeine varies significantly with individuals, but is on average 5.0
hours. The volume of distribution is 0.60 L/kg. Joe has a mass of 70 kg and is an
average subject with regard to caffeine pharmacokinetics. He has a regular habit
of consuming a cup of coffee (85 mg of caffeine) at 8 am.
What is the clearance value (CL) of caffeine in a normal individual? -
ANSWER>>0.083 L/hr/kg
Which of the following routes is most likely to be affected by the first-pass
effect? - ANSWER>>oral
A drug, given as a 150 mg single dose, results in a peak plasma concentration of
10 ug/mL. The apparent volume of distribution is (rapid distribution and
negligible elimination prior to measuring the peak plasma level): - ANSWER>>15
L
Which of the following are routes of drug clearance?
-renal
,-sweat
-intestines - ANSWER>>all of the above
What factor(s) may reduce drug bioavailability?
-gastric acid instability
-first-pass affect
-exposure to digestive enzymes - ANSWER>>all of the above
What type of receptor is the muscarinic receptor? - ANSWER>>G-protein
coupled receptor
For a cholinesterase modified by an organophosphate compound (e.g. soman),
what is the time-dependent dealkylation process called yielding an enzyme
refractory toward reactivation? - ANSWER>>aging
Muscarinic receptors bind - ANSWER>>acetylcholine
Which of the following is a clinical use for a muscarinic agonist? -
ANSWER>>"switching on" the urinary tract after surgery
, Indirect cholinergic agonists cause - ANSWER>>inhibition of
acetylcholinesterase and a corresponding increase in the synaptic acetylcholine
levels
Which of the following is characteristic of the sympathetic nervous system? -
ANSWER>>responded predominate during physical activity or when
experiencing fright
A patient with an acute attack of glaucoma is treated with pilocarpine. The
primary reason for its effectiveness in this condition is its: - ANSWER>>ability to
lower intraocular pressure
Put the following steps in the correct order for neurotransmission at the
cholinergic neuron - ANSWER>>1. acetylcholine is synthesized from choline and
acetyl-CoA
2. acetylcholine is released from storage vesicles into the synaptic cleft
3. acetylcholine is synthesized from choline and acetyl-CoA
4. acetylcholine is degraded by acetylcholinesterase
The autonomic nervous system innervates all of these except -
ANSWER>>skeletal muscle
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