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Exam (elaborations)

NR 565 Midterm Exam with correct answers

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NR 565 Midterm Exam with correct answers

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  • September 17, 2024
  • 17
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NR565
  • NR565
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Lectphilip
NR 565 Midterm 2024-2025 Exam with
correct answers

When |prescribing |Medications, |we |must |understand |that |the |liver |function |declines |with |age |d/t |
what?

A. |Enlarged |Liver

B. |Decreased |blood |flow |to |liver

C. |Increased |activity |of |the |hepatic |enzymes |- |correct |answer-B. |Decreased |blood |flow |to |liver



An |82 |yo |male |visits |the |clinic |complaining |that |his |pain |meds |"take |forever" |to |work |after |he |
takes |his |pill. |What |are |possible |reasons |you |can |explain |to |him |as |to |why |this |may |be |
happening.



A. |Perhaps |we |need |to |increase |your |dose

B. |Sometimes |as |you |get |older, |absorption |may |be |slower |resulting |in |a |delayed |response

C. |As |we |get |older, |the |gastric |acid |decreases |and |may |delay |absorption |- |correct |answer-B. |
Sometimes |as |you |get |older, |absorption |may |be |slower |resulting |in |a |delayed |response

C. |As |we |get |older, |the |gastric |acid |decreases |and |may |delay |absorption



RA |Characteristics



Onset

Affected |population

Location

Joint |stiffness |duration

SxS |- |correct |answer-weeks-months

women>men

common |hands, |feet, |& |wrists

>60 |min |in |AM

,local |& |sys.



OA |Characteristics |



Onset

Affected |population

Location

Joint |stiffness |duration

SxS |- |correct |answer-years

men |& |Women |equally

Hands |& |weight |baring |joints |

<30min |in |AM

typically |local



What |might |you |expect |to |find |in |the |synovial |fluid |of |a |pt |with |OA |- |correct |answer-Mild |
leukocytes



What |might |you |expect |to |find |in |the |synovial |fluid |of |a |pt |with |RA |- |correct |answer-Cloudy |with |
leukocytes



Goals |of |Tx |for |RA |- |correct |answer-Sxs |relief |(pain, |stiffness, |inflammation,

maintaining |joint |fxn |and |ROM

minimize |systemic |involvement

delay |progression



Typical |pharm |Txs |for |RA |- |correct |answer-NSAIDs, |systemic |steroids, |antimalarials, |antimetabolites,
|and |biologics




Baseline |assessment |data |before |starting |DMARD |- |correct |answer-Liver, |PG, |serum |creatinine, |CBC
|with |diff, |sxs |of |infxn |(TB |& |hepatits), |Hx |& |physical, |renal |status, |& |malignancies

, Significant |baseline |data |for |Sulfasalazine |- |correct |answer-CXR, |pulmonary |and |neuro |status



Significant |baseline |data |for |Leflunomide |- |correct |answer-CXR, |BP |& |pulmonary |status



Significant |baseline |data |for |Mehtotrexate |- |correct |answer-CXR, |Pulmonary |and |GI |status



Significant |baseline |data |for |hydroxychloroquine |- |correct |answer-Ophthalmologic |& |cardiac |exam |
(ECG |if |indicated)



Conventional |DMARDs- |examples |- |correct |answer-Methotrexate, |hydroxychloroquine, |sulfsalazine



Biologic |DMARDS- |examples |- |correct |answer-adalimumab, |etanercept, |golimumab



"-mab"s



MOA |of |methotrexate |- |correct |answer-folic |acid |antagonist |->inhibits |lymphocyte |proliferation



Within |how |many |months |of |RA |diagnosis |should |Methotrexate |be |started |and |why? |- |correct |
answer-3 |months |of |diagnosis



delay |joint |degeneration



What |routine |monitoring |is |needed |for |Methotrexate? |- |correct |answer-Periodic |liver |& |renal |fxn



What |blood |level |do |we |expect |to |see |elevated |in |a |patient |with |gout? |- |correct |answer-Uric |acid



First |line |Tx |for |gout |- |correct |answer-Corticosteroids, |NSAIDs, |or |Colchicine

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