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PC 707 Final Safety Exam Questions And Accurate Answers
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PC 707 Final Safety Exam Questions And Accurate AnswersIgE mediated allergic reaction that occurs following the 2nd exposure to antigen? -
Answer Type I Immediate hypersensitivity
Delayed Allergic reaction involving T cell in skin? - Answer Type IV Reaction
Primary treatment for a Type 1 Allergic response? - Answer Epinephrine
Adjunctive treatment for a Type 1 Allergic response - Answer ‣ H1 Blockers
‣ Corticosteroids help prevent bi phasic reactions
‣ Bronchodilators provide some relief-
One of the most Severe forms of a Type IV allergic reactions. - Answer ‣ Stevens
Johnson Syndrome
‣ Toxic epidermal necrolysis
When considering a drug "re challenge" after reaction what are crucial factors the
APRN must consider? - Answer ‣ What drug the patient reacted to
‣ The severity of the reaction (never again in Type I or severe type IV) *most important*
What Black Box Warning does Carbamazepine & Lamictal carry? - Answer Potential
life-threatening dermatologic reaction, including Steven's Johnson and Toxic Epidermal
Necrolysis
What Black Box Warning does Promethazine (Phenergan) antiemetic carry? - Answer
Potential for life threatening respiratory depression in children.
, What Black Box Warning do Fluoroquinolones carry? - Answer Potential for tendon
rupture
What Black Box Warning does SSRIs carry? - Answer Potential increased risk of suicide
in teens.
What Black Box Warning does opioids carry? - Answer Combining opioids &
benzodiazepines can cause extreme sleepiness, slowed breathing & death
Insulin/Sulfonaureas adverse effect - Answer Hypoglycemia!
Tricyclic Antidepressants - Answer Very risky for overdose
Nitrofurantoin (Macrobid) adverse effect - Answer Pulmonary Toxicity (rare )
Proton Pump Inhibitors Increases the risks for - Answer ‣ Upon starting: Community
acquired pneumonia
‣ Over time more likely to get infections like TB
‣ In the long term possible increased risk of fracture
Bisphosphonates possible risk - Answer osteonecrosis of jaw
As we age our kidneys shrink & there is reduced blood flow through the kidneys. Why is
this a prescribing consideration? - Answer Reduced renal excretion of drugs
As we age, our liver become smaller, has decreased blood flow & first pass metabolism
decreases Why is this a prescribing consideration? - Answer Decreased liver size also
means decreased production of CYP 450 enzymes!
So if you need to select a drug for the elderly try to select drugs that use Phase 2
metabolism (not affected by age) Phase I is affected & involves the CYPs.
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