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BMSC207- Module 9 Test with Questions and 100% Correct Answers
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BMSC207- Module 9 Test with Questionsand 100% Correct Answers
what do smooth muscle cells that respond to graded stimulation or action potentials
produce? - Answer an influx of Ca through voltage-gated L-type Ca channels
what can IP3 pathways cause? - Answer contraction with minimal depolarization and
negligible extracellular Ca influx
what does depletion of Ca in the SR cause? - Answer activation of store-operated
channels
what does the activation of store-operated channels cause? - Answer a Ca influx
across the cell membrane. allows Ca to remain elevated and replenishes SR
what do Orai-q proteins make up? - Answer Ca channel on cell membrane
what is pharmacomechanical coupling? - Answer when Ca is release from DR via
IP3 pathway and entry of Ca via store operated channels are voltage independent
what does a stretch of smooth muscle cause? - Answer - an internal release of Ca from
the SR through the ryanodine receptor
- phosporylation of the myosin light chain leading to contraction
True or false. in smooth muscle myosin ATPase must be activated. - Answer True
, what is myosin light chain kinase (MLCK)? - Answer the Ca - Calmodulin complex then
activated an enzyme
what must the regulatory light chain be dephosphorylated by? - Answer myosin
light chain phosphatase
what is the latch state? - Answer when even after dephosphorylation of regulatory light
chain some smooth muscle can maintain force for an extended period of time with
little ATP
how can neurotransmitters, hormones and paracrine molecules alter smooth muscle
Ca sensitivity? - Answer by modulating myosin light chain phosphatase (MLCP)
what does the contractile force in smooth muscle largely depend on? - Answer the
balance of MLC phosphorylation and dephosphorylation
what is MLC phosphorylation regulated by? - Answer the Ca - CaM complex, ehich in
turn depends on levels of intracellular Ca
which type of muscle can regulate Ca over the widest range? - Answer smooth muscle
how to you have contractile control? - Answer by regulating Ca sensitivity of proteins
regulating contraction
what makes you have greater contraction at lower Ca? - Answer inhibiting MLCP
or activating MLCK
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