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MICR 270 Exam Study Guide with Questions and 100% Verified Answers
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MICR 270 Exam Study Guide withQuestions and 100% Verified Answers
Neutrophils - Answer Most abundant, 1st to arrive, short life span, and have
both phagocyte and granulocyte abilities.
Granulocyte -> have a polymorphic nucleus and granules containing lytic enzymes.
Phagocyte -> can engulf and absorb bacteria.
Basophils - Answer Non-phagocytic granulocytes that contain a polymorphic
nucleus and granules containing pharmacologically active substances.
Have largest granules and are least common granulocyte.
Play role in allergies.
Susceptible to staining by basic dyes.
Eosinophils - Answer Phagocytic granulocytes that play a role in defense against
multicellular parasites and stain by an acidic red-colour called eosine.
Granulocyte -> polymorphic nucleus and granules that can damage parasitic
membranes.
Phagocyte -> minor role compared to neutrophils
Dendritic cells - Answer Arise from myeloid or lymphoid progenitor cells and are part
of both the innate and adaptive immunity.
,Capture and engulf pathogens and present them to cells of the adaptive immune
response to initiate it.
Help communicate between branches of the immune system.
Langerhans DC is a subtype located under surface epithelium of the skin and in
mucous membranes.
Lymphoid progenitor - Answer Differentiate into the adaptive immune cells:
B-cells
-Plasmocytes
-Memory B-cells
T-cells
-Helper T-cells
-Cytotoxic T-cells
-Memory T-cells
Can also differentiate into NK cells of the innate system.
Natural Killer cells - Answer Granular lymphocytes containing perforin and granzymes.
Can recognize tumor or virus-infected cells despite lacking antigen-specific receptors.
Can distinguish and kill abnormal cells.
T-cells - Answer Cell mediated immunity
Mature in thymus
Non phagocytic
Have T-cell receptors (TCR)
Specificity -> one T-cell expresses many TCR that recognize the same specific antigen or
epitope.
, Diversity -> every t-cell in the body recognizes a different antigen by TCR specificity.
Helper T-cells - Answer Aka CD4+ T-cells due to expression of CD4 costimulatory
molecule.
Activate when they see the antigen MHC II complex.
Effector cells -> when activated, helper T-cells play a role in activation of other
immune cells such as B-cells, cytotoxic T-cells, and macrophages.
Memory cells -> activated helper T-cells also generate memory cells that recognize
the same specific antigen if the pathogen re-infects the body.
Cytotoxic T-cells - Answer Specialized T-cells that express CD8 costimulatory
molecules, therefore they are aka CD8+ T-cells.
Activate when they recognize antigen-MHC class I complex.
Effector cells -> play a key role in monitoring the cells of the body and eliminating any
cells that display foreign antigens (i.e. virus infected cells)
Memory cells -> if pathogen re-infects body a stronger and quicker response is initiated.
B-cells - Answer Humoral immunity
Mature in bone marrow
Non phagocytic and have B-cell receptors (BCR)
Specificity -> one B-cell expresses many BCR that recognize the same
specific antigen/epitope.
Diversity -> every B-cell in the body recognized a different antigen through
BCR specificity.
Plasmocytes - Answer Effector form of activated naïve B-cells
Produce and secrete antibodies that can bind free pathogens or foreign molecules.
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