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NPLEX 2 Pharm Questions and Correct Answers | Latest Update
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5-fluorouracil -:- ANTI-NEOPLASTIC/ ANTI-METABOLITE IND: - Carcinoma of the breast, colon, head and neck, pancreas, rectum or stomach - TOPICAL for management of actinic (solar) keratosis, superficial basal cell carcinomas ACT: - Pyrimidine antimetabolite, blocks methylation of deox...

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  • September 19, 2024
  • 154
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

Subjects

  • nplex 2 pharm questions and correct answers late
  • 5 fluorouracil anti neoplastic anti metabol

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2024 /2025 | © copyright | This work may not be copied for profit gain Excel!




NPLEX 2 Pharm Questions and Correct
Answers | Latest Update
5-fluorouracil


✓ -:- ANTI-NEOPLASTIC/ ANTI-METABOLITE

✓ IND:

✓ - Carcinoma of the breast, colon, head and neck, pancreas, rectum or

stomach

✓ - TOPICAL for management of actinic (solar) keratosis, superficial basal

cell carcinomas

✓ ACT:

✓ - Pyrimidine antimetabolite, blocks methylation of deoxyuridylic acid and

interferes with DNA synthesis

✓ - Stops thymidilate synthase.

✓ A/E:

✓ - Dermatitis, vomiting, diarrhea, alopecia, heartburn, nausea, anorexia,

stomatitis, esophagitis, leukopenia, GI ulceration, myelosuppression

✓ C/I:

✓ - Poor nutritional status, depressed bone marrow fcn, thrombocytopenia,

major surgery w/in the previous month, PREGNANCY, enzyme deficiency

✓ INT:



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,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!



✓ - Decreased effect from methotrexate

✓ - Cimetidine, leucovorin increase levels

✓ - Avoid ethanol

✓ MONITOR: CBC w/ differential, platelet count, renal and LV fcn tests

✓ Rx: IV or topical




Acetaminophen


✓ -:- NON-NARCOTIC ANALGESIC/ ANTIPYRETIC (Tylenol)

IND:


- Mild pain, acute MSK pain, OA, RA, fever


ACT:


- Inhibits CNS prostaglandin synthesis, analgesic, anti-pyretic, NOT anti-inflammatory, Does

not affect platelet agg or uric acid metabolism


A/E:


- MAY INHIBIT CARTILAGE FORMATION, HEPATITIS (BLACK BOX WARNING FOR

HEPATOTOXICITY)


- Preg B


- OD can cause potentially lethal hepatotoxicity (overwhelms glutathione detox system in

LV), or nephrotoxicity

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,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!



- ANTIDOTE; Charcoal, N-Acetylcysteine (glutathione precursor).


C/I:


- LV dz, LV failure, alcoholism


INT:


- Barbituates, carbamazepine, phenytoin, isoniazid OBCP, and rifampin all activate LV

breakdown of acetaminophen and cause it to be more hepatotoxic and less active.


- Acetamin. may decrease activity of lamotrigine, zidovudine and loop diuretics,


- May interfere w/ home glucose monitors.


**Monitor for HEPATOTOXICITY W/ INGESTION > 4g/DAY




Acyclovir


✓ -:- ANTIVIRAL (Inhibits DNA polymerase)

IND:


- HSV ixn and prevention, VZV, EBV, disseminated neonatal herpes, CMV ixn


ACT:


- Nucleoside analog inhibiting viral replication, NON-CURATIVE


A/E:




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, 2024 /2025 | © copyright | This work may not be copied for profit gain Excel!



- HA, diarrhea, nausea, delirium, tremor, Htn, transent renal dysfunction w/ high doses,

encephalopathy (IV), CAN PROMOTE EMERGENCE OF RESISTANT STRAINS


C/I:


- Preg C


INT:


- Synergistic toxicity w/ ZIDOVUDINE (AZT).


MONITOR: urinalysis, BUN, serum creatinine, LV enz, CBC


Rx: Oral, topical, IV




Adalimumab


✓ -:- DMARD (Antirheumatic, TNF-alpha inhib)

IND:


- RA, psoriatic arthritis, ankylosing spondylitis, Crohn's dz, severe psoriasis, JRA


ACT:


- Fully-humanized anti TNF-alpha IgG; anti-inflammatory and immunosuppressive


A/E:


- injection site rxn's, increased risk of dangerous ixn's (TB), herpes zoster re-activation,

cancers (ESP LYMPHOMA IN CHILDREN)

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