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NUSC 3P14 Pharmacology Exam Questions And Accurate Answers
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NUSC 3P14 Pharmacology ExamQuestions And Accurate
Answers
Donepezil (Aricept) - Answer acetylcholinesterase inhibitor
Rivastigmine (Exelon) - Answer acetylcholinesterase inhibitor
Galantamine ER (Reminyl ER) - Answer anticholinesterase inhibitor
Memantine (Namenda) - Answer NMDA receptor antagonist
- allows Ca to enter cells to prevent excessive neuronal stimulation
Donepezil & Memantine (Namzaric) - Answer cholinesterase inhibitor and NMDA
receptor antagonist
Anticholinesterase inhibitors - Answer - prevent breakdown of AcH (NT important for
learning and memory)
- supports communication among nerve cells by keeping AcH high
NMDA receptor antagonist - Answer decreases activity of glutamate (NT has role in
information processing, storage and retrieval)
Alzheimer's Disease - Answer decreased AcH (alters learning, memory, mood)
increased glutamate (overexposure of Ca)
SSRIs (selective serotonin reuptake inhibitors) - Answer - selectively inhibits serotonin
reuptake into the presynaptic neuron
- greater tolerability, ease of dosing and safety in OD
- DON'T prescribe with MAOI/other serotonin drugs
- Side effects: GI upset, insomnia, drowsiness, anticholinergic effects, sexual
dysfunction, weight gain(longterm) /loss (short)
Citalopram (Celexa) - Answer SSRI
Escitalopram (Cipralex) - Answer SSRI
Fluoxetine (Prozac) - Answer SSRI
, Fluvoxamine (Luvox) - Answer SSRI
Paroxetine (Paxil) - Answer SSRI
Sertaline (Zoloft) - Answer SSRI
SNRIs (serotonin-norepinephrine reuptake inhibitors) - Answer - inhibits the reuptake of
serotonin and norepinephrine into the presynaptic neuron
- first-line agents
- similar side effects as SSRIs
- HTN can occur @ high doses (sympathetic increase) - HTN crisis
Venlafaxine (Effexor XR) - Answer SNRI
Duloextine (Cymbalta) - Answer SNRI
Desvenlafaxine (Pristiq) - Answer SNRI
Serotonin Syndrome - Answer With any drug that increases 5-HT (e.g., MAO inhibitors,
SNRIs, TCAs)
- life threatening
- confusion, hallucinations, uncoordinated movements, agitation, headache, tremors,
fever, coma
-Treatment: cyproheptadine (5-HT2 receptor antagonist) and symptomatic treatment
Bupropion (Wellbutrin) - Answer - Norepinephrine and dopamine reuptake inhibitor
(NDRI)
- first-line agent
- insomnia, dry mouth, agitation, constipation, increased risk of seizure (contra head
injury, epilespsy)
- LESS sexual dysfunction
- smoking cessation ****
Trintellix (Vortioxetine) - Answer - serotonin modulator & stimulator
- thought to inhibit the reuptake of serotonin and causes receptor antagonism
- N+V, constipation
Tricyclic Antidepressants (TCAs) - Answer - first generation
- start low dose, gradually increase, slow taper off
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