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Galen NUR 210 Exam 1 Modules 1-3 questions with answers.
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Galen NUR 210 Exam 1 Modules 1-3questions with answers.
Pharmacokinetics ANS - The process in which medications move through the body
What are the 4 phases of pharmacokinetics? ANS - absorption, distribution, metabolism, excretion
Absorption ANS - happens with drug movement from the GI tract into the bloodstream. Most meds are
taken by mouth.
Oral absorption ANS - Takes awhile to get absorbed because it has to go through the GI system
Usually takes 2-4 hours
•Enteric coated
aspirin - hard on stomach
can not crush pill
•Extended release
absorbed in the small intestine
IM absorption ANS - Absorbed 1-2 hours
IV absorption ANS - Absorbed 30-60 minutes
dissolution ANS - Dissolution happens when a po medication breaks down into particles, disintegrates,
and dissolves to combine with liquid so absorption from the GI tract into the bloodstream occurs.
Liquid medications are absorbed faster than solids. Food can interfere with the absorption of drugs.
Drugs that resist dissolution ANS - Parenteral medications (SL, eyedrops, inhalants, transdermal) do not
pass through the GI tract.
,Enteric coated medications are designed to resist disintegration until the pill reaches the small intestine.
EC and sustained release meds should not be crushed.
Factors that affect absorption ANS - •Lack of muscle and increased fat changes medicine absorption
•Food consumption - will change medicine potency (delayed)
•Stress - Exercise, medicine goes to muscle
•pH - Medicine is made for acidic environments
•Antacid changes absorption
•Taken alone so it doesn't change the action
Excipients ANS - Fillers and other substances that make up tablets as a pill is not 100% drug.
Sometimes an excipient enhances the absorption of a drug such as with PCN, which is not well absorbed
from the GI tract.
Adding Na to PCN, which makes it penicillin sodium, will increase the absorption of PCN
first pass effect ANS - •the oral drugs go to liver via portal vein where some of the drug becomes
inactive
•Only happens with oral medications
delayed gastric emptying ANS - Food doesn't move like it should
Distribution ANS - refers to the movement of the drug from the circulation to body tissues
Factors affecting distribution ANS - -blood flow to tissues
-protein binding
-blood brain barrier
-drug's affinity to the tissue
protein binding ANS - Drugs bind with proteins in blood
Some drugs are highly protein bound and other are weakly protein bound
, free drugs ANS - drugs not bound to protein
Drug Toxicity ANS - -Two highly protein bound drugs compete and one might accumulate and cause a
toxicity
-it is important to know if you are administering highly protein bound medications and monitor albumin
levels in patients with liver or kidney disease.
-Some drugs that are highly protein bound include: Warfarin
Furosemide
Diazepam
Drug distribution and albumin ANS - -A decrease in albumin levels decrease the protein-binding sites,
which means more of the free drug is circulated.
-This can be fatal with some meds.
-Free drugs are those not bound to protein, which means they are active in the body and cause a
pharmacologic response.
-Older adults, malnourished individuals, and those with liver or kidney disease have low albumin levels.
Blood Brain Barrier (BBB) ANS - -The BBB protects the brain from most drugs.
-Some meds are able to cross the BBB such as benzodiazepines.
-Drugs can cross the placenta and cause spontaneous abortion or alter fetal growth and development.
Metabolism ANS - •Chemically changes drug to a form that can be excreted
•Liver primary site
half-life ANS - •the time it takes for the drug in the body to be reduced by half
Loading dose ANS - use of a higher dose than what is usually used for treatment to allow the drug to
reach the critical concentration (therapeutic level) sooner
•Blood thinner
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