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Exam (elaborations)

AMR EXAM 1 ANTIBIOTICS MOA QUESTIONS AND ANSWERS

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AMR EXAM 1 ANTIBIOTICS MOA QUESTIONS AND ANSWERS

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  • September 20, 2024
  • 18
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • AMR
  • AMR
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21 Multiple choice questions

Definition 1 of 21
Streptogramin A: blocks tRNA binding
Streptogramin B: blocks translocation

Sulfanilamide


Chloramphenicol

Oxazolidinones

Streptogramins

Definition 2 of 21
inhibit 50S subunit

Chloramphenicol

Tetracyclines

Aminoglycosides

Macrolides

Definition 3 of 21
Caps D-Ala-D-Ala and prevents its incorporation into peptidoglycan and subsequent
crosslinking

Metronidazole


Penicillin

Vancomycin


Bacitracin

,Definition 4 of 21
poke holes in bacterial membranes

Macrolides


Lipopeptides

Tetracyclines


Oxazolidinones

Definition 5 of 21
inhibits ADC synthase → inhibits synthesis of PABA

Abyssomicin C

Vancomycin

Cycloserine


Fosfomycin

Definition 6 of 21
inhibit DNA gyrase and DNA replication
(withdrawn form the market)

Mupirocin


Novobiocin

Vancomycin

Bacitracin

Definition 7 of 21
inhibits bacterial DHFR

Fosfomycin

Penicillin

Trimethoprim

Vancomycin

, Definition 8 of 21
Binds to 50S ribosomal subunit and inhibits the initiation complex

Macrolides


Oxazolidinones

Metronidazole

Tetracyclines

Definition 9 of 21
B-lactam antibiotics bind transpeptidases much stronger than D-Ala-D-Ala.
The binding is covalent and irreversible and results in inhibition of the enzyme, cell wall
synthesis, and consequently death by cell lysis

Methotrexate

Vancomycin

Penicillin


Trimethoprim

Definition 10 of 21
Inhibits MurA, an enzyme that catalyzes the addition of enolpyruvate to UDP-N-
acetylglucosamine

Bacitracin

Metronidazole

Vancomycin

Fosfomycin

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