Naplex BBW
all Direct Acting Antivirals (DAAs)
Risk of reactivating HBV; test all patients for HBV before starting a DAA
Ribavirin (Virazole)
significant teratogenic effects
not for monotherapy for HCV
hemolytic anemia
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interferon
can cause of exacerbate neuropsychiatric autoimmune, ischemic, or infectious disorders
teratogenic if used with ribavirin
All HBV NRTIs
lactic acidosis and severe hepatomegaly with steatosis
exacerbations of HBV
can cause HIV resistance in HBV
Lamivudine (Epivir)
Do not use Epivir-HBV; May exacerbate or cause resistance of HBV
, Adefovir (Hepsera)
caution in patients with renal impairment or those at risk of renal toxicity
Enoxaparin
Neuraxial anesthesia may cause hematomas
DOACs
Pts receiving neuraxial anesthesia (epidural, spinal) or undergoing spinal puncture are at risk of
hematomas and subsequent paralysis
A,E,R - premature discontinuation increases risk of thrombotic events
Edoxaban: reduced efficacy in nonvalvular AFib pts with CrCl > 95mL/min, do NOT use
Andexanet alfa
Thromboembolic risks, ischemic events, cardiac arrest, sudden death
kcentra
arterial and venous thromboembolic complications
prochlorperazine
increased mortality in elderly with dementia
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