PASS NAPLEX NOW Chapter 9: Labs
Normal level of AST & ALT
Normal level of Albumin
< 35 U/L
3.4 - 5.4 g/dL
Normal level of BUN
Normal level of Creatinine
Normal level of BUN / Creatinine
Range: 6 - 20 mg/dL
Range: 0.6 - 1.3 mg/dL
Range: 10 - 20
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Normal level of Sodium
135 - 145 mEq/L
,Normal level of Potassium
3.5 - 5.2 mEq/L
Normal level of Glucose
70 - 100 mg/dL
(True or False) ALT and AST are indicators of liver injury, not liver function
True
Liver Functions
1) Albumin synthesis
2) Bilirubin clearance
3) Ammonia clearance
4) Clotting factors 2,7,9,10 synthesis
5) Cholesterol production
Liver failure (Cirrhosis)
1) ↓ Albumin --> Ascites/Edema
2) ↑ Bilirubin --> Jaundice
3) ↑ Ammonia --> Hepatic Encephalopathy
4) ↓ Factors 2,7,9,10 --> ↑ INR --> Bleeding
5) ↓ Cholesterol
Tx of Hepatic Encephalopathy
, 1) Lactulose: 2 - 3 (Large Bowel Movements)
2) Rifaximin (Xifaxan) (MOA: By decreasing gut flora --> Decrease ammonia
What are some complication due to liver cirrhosis?
1) Hepatic encephalopathy
CHILD-PUGH Classification of Cirrhosis (Scores)
* Class A: 5-6 points
* Class B: 7-9 points
* Class C: 10-15 points
Measured CrCl
Urine Volume x Urine Cr / Plasma Cr x 24 h x 60 min
Calculated CrCl
(140-Age) x (Weight in kg) / Plasma Cr x 72 (Multiply by 0.85 for females)
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