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MSN 611 Midterm Exam Questions And Verified Detailed Answers
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MSN 611 Midterm Exam Questions And VerifiedDetailed Answers 2024-2025
Histamine outside of mast cells serves as a neurotransmitter in the brain and is
implicated in neuroendocrine control, cardiovascular functions, thermal and weight
regulation, and sleep-arousal balance
which of the following cells release histamine in the stomach? -Answer
enterochromaffin-like (ECL) cells
toxicity of antihistamines has been reported in incidents of interactions with: -Answer
liver enzymes
Toxic effect of first-generation antihistamines - Answer convulsions, postural
hypotension, and cardiac arrhythmias
Know anaphylaxis - Answer
Central nervous system side effect of antihistamines in the elderly - Answer BEERs list,
Indication H2 antihistamines - Answer used to inhibit secretion of gastric cid with GI
disorders
Know initial selection of antimicrobial therapy - Answer
Mechanism of food-drug or drug-drug interactions with antibacterial medications -
Answer
,know multiple drug combination treatment for tuberculosis -Answer isoniazid, rifampin,
pyrazinamide and ethambutol for up to 9 months
know about description of IFN-β - Answer (fibroblast interferon) IFNs are biological
response modifiers w an antiviral and immunolodulatory activity. IFN-B is released by
human cells infected with certain viruses- help create resistance to viral infections by
acting on the host tissue cells
type of pathogen causes malaria - Answer plasmodium parasite?
Why systemic chemotherapy that is given before surgery or radiation is given-Answer
neoadjuvant therapy is used to reduce tumor burden and also to improve effectiveness
of the local txt (126)
Tumor lysis syndrome management in leukemia pts -Answer adequate IV hydration
therapy, & give allopurinol if hyperuricemia is expected (129)
Acrolein is a toxic metabolite of both cyclophosphamide and ifosfamide that may cause
what? -Answer hemorrhagic cystitis (131)
Classification of antineoplastic drugs, which may offer an alternative when conventional
treatments are ineffective -Answer immunosuppressant antineoplastic agents may offer
an alternative (137)
To what enzymes do the topoisomerase inhibitors target? -Answer by altering the
phosphodiester structure of the strands of DNA during the normal life cycle of the cell
Effects of cholinesterase inhibitors have on the sinoatrial and atrioventricular
nodes-Answer they exert vagotonic effects on the SA and AV nodes causing
bradycardia and AV block which may exacerbate syncope or hypotensive events
Mechanism of action of "mixed acting" sympathomimetic drugs-Answer may have direct
activation of the release of NE while also having an indirect effect causing a release of
, NE Jenny how does epinephrine cause vasodilation?
Disease for which GABA-derivative antispasmodic agents are used effectively to control
muscle spasm - Answer multiple sclerosis (227)
FDA use approved for belladonna - Answer for mod-severe pain associated with ureteral
spasm (bladder spasm) that is not responsive to non-narcotic analgesics
Time interval for the therapeutic effect of initial warfarin therapy - Answer 5-7 days after
first dose
Function of plasmin - Answer promotes hydrolysis of cross linked fibrin polymers
Derivation of antihemorrhagic agents Answer human sources- so monitor for
infusion-related reactions
Know anticoagulant therapy Answer p. 273
FDA-approved drug use in thrombocytopenia Answer anagrelide
Oprelvekin
Type of hypertensive medication should preferentially be considered for African
Americans Answer calcium-channel-blockers
Drug of choice for treating hypertension in pregnancy Answer methyldopa
Beta-blocker indicated for hypertensive emergencies Answer labetalol
Know renin-angiotensin-aldosterone inhibitors Answer Aliskiren
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