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NURS 8024 Pharm Exam 3 (Antimicrobial Part 2) – Questions With Solutions (A+) $9.99   Add to cart

Exam (elaborations)

NURS 8024 Pharm Exam 3 (Antimicrobial Part 2) – Questions With Solutions (A+)

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  • NURS 8024

NURS 8024 Pharm Exam 3 (Antimicrobial Part 2) – Questions With Solutions (A+)

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  • September 23, 2024
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  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • NURS 8024
  • NURS 8024
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NURS 8024 Pharm Exam 3 (Antimicrobial Part 2) –
Questions With Solutions (A+)

Bacterial protein synthesis inhibitors Right Ans - Clindamycin

Clindamycin Right Ans - Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability

Clindamycin mechanism of resistance Right Ans - Altered target sites
Active efflux (pushes drug out of the cell)

Clindamycin ADE Right Ans - GI upset
Skin rash
Neutropenia
Superinfections such a c diff pseudomembranous
- don't use if patient has history of c diff

Clindamycin indications Right Ans - Gram positive
Prophylaxis of endocarditis in valve patients with PCN allergy

Oxazolidinones Right Ans - New class of bacterial protein synthesis
inhibitors

Time dependent killing
Prevents formation of ribosome complex
Bacteriostatic & Bactericidal against strep

Linezolid Right Ans - Protein synthesis inhibitor
100% bioavailability orally
30% CSF penetration

Linezolid ADE Right Ans - Hematologic
Increased thrombocytopenia risk
Anemia, neutropenia, neuropathy
Optic & peripheral neuropathy
Serotonin syndrome with SSRIs

, Linezolid Indications Right Ans - Gram positive resistant
VRE, HCAP, CAP
Complicated skin & tissue infections
Off label use for TB
No resistance currently

Fluoroquinolones Right Ans - Norfloxacin (1st gen)
Ciprofloxacin & Ofloxacin (2nd gen)
Levofloxacin (3rd gen)
Moxifloxacin & Gemifloxacin (3rd gen respiratory)

Fluoroquinolones are classified by Right Ans - Generations according to
antimicrobial spectra

1st Generation Fluoroquinolone Right Ans - Narrow gram negative
Norfloxacin

2nd Generation Fluoroquinolone Right Ans - Broad- gram negative and
gram positive
Cipro & ofloxacin

3rd generation Fluoroquinolone Right Ans - More gram positive than gram
negative
Levofloxacin
Moxifloxacin
Gemifloxacin
-moxi and gemi are respiratory Fluoroquinolones

Fluoroquinolones MOA Right Ans - Inhibits DNA synthesis
Bactericidal
Concentration dependent killing
Resistance- target sites altered by mutation & change in sensitivity of target
enzymes

Fluoroquinolone ADE Right Ans - GI upset, rash, abnormal LFTs
Prolonged QTc
Tendinitis and tendon rupture (caution in pregnancy)

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