Exam (elaborations)
OCCTH 585 - Alzheimer's Disease Questions and Answers 100% Solved
- Course
- Institution
OCCTH 585 - Alzheimer's Disease Questions and Answers 100% Solved
[Show more]
Content preview
OCCTH 585 - Alzheimer's Disease Questions andAnswers 100% Solved
Density of Plaques Correct Ans-- Temporal lobe is most severely affected
- Hippocampus volume is reduced by up to 60% in advanced AD
- Reduced connectivity of the hippocampus with other brain regions
β-amyloid plaques Correct Ans-Defective breakdown of a benign substance known as
amyloid precursor protein (APP)
Produce sticky, insoluble shards of β-amyloid plaques
- stick together, form dense plaques, damage axons, lead to development of neurofibrillary
tangles
Neurofibrillary Tangles Correct Ans-Normally tau serves as connectors for a track like
structure in the cell body of every neuron for transporting nutrients
Tau somehow becomes hyperphosphorylated, destroy nutrient supply destroying neuron,
axon, dendrites, synapses
, OCCTH 585 - Alzheimer's Disease Questions and
Answers 100% Solved
(Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of
neurofibrillary degeneration)
Neural systems for AD Correct Ans-Limbic System:
- Impacts our behaviout
- Plays a role in basic instincts such as sleping and eating
- Plays a role in emotions
- impacts sense of smell
- The hippocampus, which is part of the limbic system, is important for learning and short
term memory - the part of the brain where short-term memories are converted to long-term
memory for storage - also where verbal and visual memory are processed
Circadian rhythms are affected (day-night cycle)
Suprachiasmatic necleus within the hypothalamus (circadian clock)
, OCCTH 585 - Alzheimer's Disease Questions and
Answers 100% Solved
Neurotransmitter abnormalities Correct Ans-Tracks form by cholinergic neurons
(containing acetylcholine) are destroyed
Nucleus basalis has projections to cortical areas, volume reduce by ~70% in AD
Brain Atrophy Correct Ans-Severe shrinking of the entire cortex
Severely enlarged ventricles
Severe shrinkage of hippocampus
Rate of neuronal loss accelerates as the disease progresses
Whole brain weight decreased by 10% to 19%
Not evenly distributed
Mostly in gyri of association areas
Relatively less: primary motor, primary somatosensory and primary visual cortices
-- Mostly the medial temporal lobe is affected --
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ExamRoom. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
76658 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now