NSG 520 Pathophysiology and Pharmacology
Questions With Complete Solutions
What is the mechanism of action of interferon alfa?
Interferon alfa has multiple effects on the viral replication cycle.
After binding to receptors on host cell membranes, the drug
blocks viral entry into cells, synthesis of viral messenger RNA
and viral proteins, and viral assembly and release.
All of the interferons used for hepatitis belong to what class?
Alpha
Interferon alpha can cause liver failure.
False
Interferon alpha is available orally
False
The incidence of side effects when taking interfere on alpha
diminish with continued therapy.
True
,Prolonged or high dose therapy of interferon alpha can cause
which of the following? Select all that apply.
Thyroid dysfunction
Heart damage
Bone marrow suppression
Patients taking interferon alpha who experience depression may
respond to anti-depressant medication.
True
Protease inhibitors are also known as direct acting antivirals.
True
The nurse is preparing to administer interferon alfa. Which of
the following are true regarding this drug? Select all that apply.
Neuropsychiatric adverse effect risk
Interrupts viral replication cycle
Monitor injection site closely for reaction
The side effects of alpha interferons include which of the
following? Select all that apply.
Depression
,Leukopenia
Flu-like syndrome
The flu-like syndrome side effect caused by interferon alpha
may be treated with acetaminophen
True
Interferon alpha frequently causes neuropsychiatric side effects
especially
Depression
Which of the following is accurate about the neuropsychiatric
side effects of interferon alpha therapy? Select all that apply.
Depression is common with large doses and prolonged treatment
Reduction of interfere on alpha dose may be indicated with
persistent depression
Depression response to anti-depressant drugs in many patients
Oral ribavirin combined with an interferon alpha greatly
improves response rates during therapy.
True
The nurse is preparing to administer interferon alfa. Which of
the following are true regarding this drug? Select all that apply.
, Most common adverse effects are a flu-like syndrome
Monitor injection site closely for reaction
Neuropsychiatric adverse effect risk
Oral ribavirin [Rebetol, Ribasphere, Copegus], combined with
subcutaneous peginterferon alfa, is the traditional treatment of
choice for hepatitis C virus infection.
True
The most common side effects of all formulations of interferon
alpha include which of the following? Select all that apply.
Fever
Myalgia
Headache
Neuropsychiatric effects
Selective toxicity is defined as the ability of a drug to injure a
target cell or target organism without injuring other cells or
organisms that are in intimate contact with the target. As applied
to antimicrobial drugs, selective toxicity indicates the ability of
an antibiotic to kill or suppress microbial pathogens without
causing injury to the host. Selective toxicity is the property that
makes antibiotics valuable. If it were not for selective toxicity—
that is, if antibiotics were as harmful to the host as they are to
infecting organisms—these drugs would have no therapeutic
utility.
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