Exam (elaborations)
AMR EXAM 3 MATERIAL QUESTIONS AND ANSWERS
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AMR EXAM 3 MATERIAL QUESTIONS AND ANSWERS
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Name: Score:175 Multiple choice questions
Term 1 of 175
What drug plays a major role in bacterial attacks?
Immunosuppressant drugs
-Age
-Conditions(diabetes)
increases stability
implement
Term 2 of 175
increased stimulation of the immune system can cause ___
autoimmune disease
increases stability
additive or synergistic effect
• MW <500 Da
• H-bond donors <5
• H-bond acceptors <10
• Octanol-water partition coefficient <5
Term 3 of 175
What are some examples of prodrugs?
Prontosil & Isoniazid
Lifestyle
Diet
Hygiene
Prediction of target-binding molecules (molecular docking)
used for B-lactamase testing
test strain shows carbapenamase activity
,Term 4 of 175
What will happen as a result of enhancement of drug penetration.
stimulates rational drug design research\
-drug modfication
-inhibition of efflux pumps
both poke holes in bacterial components
promotes good lab practices & supports labs in national surveillance system
Severe burns
Cancer
Cystic Fibrosis
HIV/AIDS
Diabetes
Organ Transplant
Term 5 of 175
The tea that hippocrates recommended from willow tree bark was used to treat ____
TRUE
fever
Yes
less
Term 6 of 175
Morphological Identification
promotes good lab practices & supports labs in national surveillance system
not 100% effective= selection for resistance
Microscopy & Staining (examples: motility, gram staining, etc)
need a super high quantity to have an effect, maybe wound dressing
,Term 7 of 175
Host-directed antimicrobials are drugs that both ___ and ___ infection by targeting host cells
Brucella abortus
drugs that prevent or treat infection by targeting host cells
TRUE
prevent & treat
Term 8 of 175
Antibacterial effectiveness of honey can vary by 100x
True
False
Term 9 of 175
antibacterial effects of garlic might not work in vivo because of __ and __ (2 reasons)
concentration & metabolism
True
A- intracellular pathogens
design flaws & no difference
, Term 10 of 175
Define the Warburg Effect caused by Brucella abortus
promotes good lab practices & supports labs in national surveillance system
• Herpes simplex infection • Influenza • Rheumatic fever • Recurrent cellulitis •
Meningococcal disease • Pertussis • Recurrent uncomplicated UTI • Spontaneous
bacterial peritonitis in cirrhosis patients • Infective endocarditis • Acute necrotizing
pancreatitis • Open fractures • Prosthetic
Only use antibiotics when prescribed by a certified health professional. • Never demand
antibiotics if your health worker says you don't need them. • Always follow your health
worker's advice when using antibiotics. • Never share or use leftover antibiotics
This is glycolysis (not ox phos) producing lactate even in the presence of oxygen. This
process is called Aerobic Glycolysis. This only happens in cancer cells and results in a
high intake of glucose.
Term 11 of 175
What is the Waksman revival?
Methods of in situ cultivation followed by domestication will enable drug discovery from
this previously inaccessible source
• Combined with rapid dereplication, this is likely to lead to the revival of the Waksman
platform
Resistance rapidly develops against compounds hitting a single target, which
automatically eliminates the vast majority of targets
UK- insufficient evidence, no recommendation for prophylaxis in effect
Europe/ USA- recommends prophylaxis prior to procedures for patients at risk of
infective endocarditis
Require education and training accrediting bodies to include a model curriculum in
IP&AS that is taught at all levels of healthcare and continuing worker education.
Incorporate existing recommended core competencies
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