Typical Van der Waals energies are about: - Correct Answer 2-4 kJ/mol
A possible drug to treat COVID-19 has been discovered and is known to be a weak acid. At the pH of blood (7.4) the concentrations of acid and conjugate base are 0.075 and 0.025 respectively. What is its pKa? - Correct Answer...
Biochemistry 1430 midterm Questions And Correct
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Typical Van der Waals energies are about: - Correct Answer 2-4 kJ/mol
A possible drug to treat COVID-19 has been discovered and is known to be a weak acid. At the pH of
blood (7.4) the concentrations of acid and conjugate base are 0.075 and 0.025 respectively. What is its
pKa? - Correct Answer 3.00
What is the [A-]/[HA] ratio whent he weak acid is in solution alone pH unit above its pKa? - Correct
Answer 10:1
What are the primary chemical components present in a phosphate buffer at pH 7.4? - Correct Answer
H2PO4- and HPO4-2
Citric acid is an important intermediate in glucose metabolism that contains three carboxylic acid groups,
and is synthesized in mitochondrial matrix. The three pKa values for each of the carboxylic acids are 3.1,
4.8, and 6.4. What would the charge be on a citrate molecule formed in the mitochondrial matrix where
the pH is 7.8? - Correct Answer -3
Which of the following amino acids would most likely be soluble in a nonpolar solvent such as benzene?
- Correct Answer Val
Amino acid side chain (R, variable) groups contain all of the following functional groups except: - Correct
Answer ether
Which amino acid has a carboxyl group in its side chain? - Correct Answer Glu
What charged group(s) is/are present in glycine at a pH of 7? - Correct Answer -NH3+ and -NH2+
Below is a list of five tripeptides. Which tripeptide is negatively charged at a physiological pH? - Correct
Answer Met-Asp-Glu
,In the formation of the alpha helix, the carbonyl group is connected by: - Correct Answer a hydrogen
bond not with a neighboring NH group, but with a NH group located at a distance of four amino acid
residues from it.
Which of the following proteins does NOT have Quaternary structure? - Correct Answer Myoglobin
All of the following would disrupt quaternary structure except: - Correct Answer treating with ascorbic
acid
Which of the following secondary structures would you expect to find on the surface of a globular
protein? - Correct Answer alpha helix, beta sheet and loops between two alpha-helices as long as the
polar and charged amino acid side chains face the surface of the protein
Which of the following amino acid residues would most likely be buried in the interior of a water-soluble,
globular protein? - Correct Answer Phe
Which of the following is true? - Correct Answer None of the above (Ch.6)
The class of enzymes called ligases: - Correct Answer joins two molecules in a reaction powered by ATP
hydrolysis.
How many major classes can enzymes be divided in to? - Correct Answer 6
The molecular structure that is short-lived and neither substrate nor product is known as: - Correct
Answer transition state
The Gibbs free energy of activation is: - Correct Answer the difference between the substrate and the
transition state free energies.
Allosteric effectors alter the equilibria between: - Correct Answer the R and T forms of the enzyme.
allosteric enzymes: - Correct Answer contain distinct regulatory sites and have multiple active sites AND
, display cooperativity.
When substrate concentration is much greater than KM, the rate of catalysis is almost equal to: - Correct
Answer Vmax
When reaction conditions are such that the amount of substrate is far greater than the amount of
enzyme present, then the following condition is also met (choose one). - Correct Answer The enzyme is
displaying zero-order kinetics
A critical feature of the Michaelis-Menten model of enzyme catalysis is: - Correct Answer formation of
an enzyme-substrate complex.
In the double-reciprocal plot of the rate of catalysis depending on substrate concentration, the intercept
with the y axis is the same in the presence and in the absence of the inhibitor. Choose the correct type of
inhibitor. - Correct Answer competitive
What is the typical form of the curve describing dependence of enzymatic activity on temperature? -
Correct Answer bell-shaped curve with one maximum
An enzyme inhibitor that alters the apparent Vmax but not the Km would be an example of what type of
inhibition? - Correct Answer noncompetitive
In what type of inhibition can the inhibitor only bind to the ES complex? - Correct Answer
uncompetitive
A drug company has developed a new drug to treat dementia by acting as a competitive inhibitor of a
brain enzyme that is involved in damage of neurons. When they tested this inhibitor in the lab, which of
the following results would you expect? - Correct Answer The effect of the drug can be abolished by
giving the cells some of the substrate for the enzyme
Carbon dioxide forms carbamate groups in proteins by reaction with: - Correct Answer N-terminal
amino groups.
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