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NSG 533 Adv Pharm: Module 1: GI: Chp 17 Questions With All Correct Answers 2024/2025
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NSG 533 Adv Pharm: Module 1: GI: Chp 17 Questions With All Correct Answers 2024/2025
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NSG 533 Adv Pharm: Module 1: GI: Chp17
Which drug class is handiest in treating erosive lesions:? - ANSPPIs
Name four H2RAs: - ANSCimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
What is the motion of H2RAs? - ANSDecrease acid secretion by way of blocking off histamine
2-receptors in gastric parietal cells
Name 4 blessings of H2RAs - ANS1. Relieve GERD signs
2. Can be administered prophylactically
three. More powerful at controlling continual GERD signs than ANTACIDS
4. Intermittent & recurring dosing feasible based on diploma of symptom manage needed.
Name 2 drawbacks of H2RAs - ANS1. Less powerful in controlling continual GERD signs and
symptoms than PPIs
2. Renal removal might also require dose adjustment in kidney disorder patients
What are the aspect effects associated with H2RAs? - ANSH/A, nausea (Cimetidine),
susceptible inhibitor, not unusual drug interactions, gynecomastia, & Vit B-12 deficiency which
affects sufferers' tolerance
Name the advantages of Antacids - ANS1. Useful for intermittent remedy of GERD signs and
symptoms
2. Immediate symptom relief
three. Usually well-tolerated
What are the drawbacks of Antacids? - ANS1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids might also result in electrolyte imbalances esp.
In pts. W/renal impairment
3. May intrude w/absorption of fluoroquinolones, tetracyclines, iron merchandise, & thyroid
hormones
(doses have to be several hours aside)
What are the aspect outcomes of Antacids? - ANSMay purpose
Constipation or Diarrhea depending on the formula used
, What is the Pharmacological Therapy Effectiveness of Antacids? - ANSAntacids in short
neutralize gastric acid however lacks acid-suppressive homes & are not as good as H2RAs
What is the Pharmacological Therapy Effectiveness of H2RAs? - ANSHistamine-2 Receptor
Antagonists lower acid secretion to a lesser extent than PPIs (& are consequently not as good
as PPIs)
What is the Pharmacological Therapy Effectiveness of PPIs? - ANSProton Pump Inhibitors
block the fee-restricting step in acid secretion from gastric parietal cells & block all pathways for
gastric acid secretion & consequently are higher than H2RAs
What is the remedy goal of pharmacological therapy in GERD? - ANSIncrease the pH of gastric
content by using; 1) Direct gastric acid neutralization 2) Reduce acid production through
inhibiting the stimulation of pathways to lower GERD signs and symptoms and save you tissue
harm
Which Bariatric Surgery is effective in decreasing GERD symptoms in obese patients? -
ANSRoux-en-Y gastric skip
Which Bariatric Surgery is ineffective in reducing GERD symptoms in overweight patients? -
ANSVertical banded gastroplasty
Which is greater beneficial in esophagitis symptom manage; Omeprazole or Antireflux surgical
procedure? - ANSIn a 7-yr follow-up have a look at, Antireflux surgical procedure provided more
symptom manage in esophagitis sufferers
Name four Factors indicating while Antireflux Surgery is the perfect option for sufferers
w/properly documented GERD: - ANS1) S/Es are insupportable/undesired
2) Adherence is a task
three) Large Hiatal Hernia is present
four) Refractory GERD symptoms
What is Antireflux Surgical Fundoplication? - ANSA surgery which will increase LES (lower
esophageal sphincter) pressures by using wrapping the fundus (upper part) of the stomach
across the distal quit of the esophagus
What are LES stimulators? (5/5) - ANSAntireflux tx. Choice & alternative to fundoplication
surgery: LES stimulators are surgically inserted to modulate LES pressures and decrease
refluxate from the belly
What is LINX? (4/five) - ANSAntireflux tx. Alternative & opportunity to fundoplication surgery in
which bands of interlinked titanium beads with magnetic cords are placed across the LES to
help in preserving LES pressure
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