WHAT CONVERTS YELLOW BONE MARROW TO HEMATOPOIETIC RED MARROW? -
ANSWER: ERYTHROPOIETIN
WHERE IS ERYTHROPOIETIN PRODUCED? - ANSWER: PERTIBULAR CELLS OF KIDNEY
WHAT FEEDBACK LOOP IS USED IN ERYTHROPOIESIS? - ANSWER: NEGATIVE
FEEDBACK LOOP
,WHEN IS ERYTHROPOIETIN RELEASED? - ANSWER: IN RESPONSE TO LOW RENAL
OXYGENATION
HOW FAST CAN ERYTHROPOIETIN INCREASE RBC PRODUCTION? - ANSWER: 24
HOURS
INCREASED RBC NUMBER IN 5 DAYS
WHAT IS ERYTHROPOIETIN LIFE SPAN? - ANSWER: 4-12 HOURS
ERYTHROPOIETIN IS ALWAYS PRESENT WHERE? - ANSWER: IN THE PLASMA
WHAT TYPES OF PATIENTS ARE GIVEN ERYTHROPOIETIN? - ANSWER: DIALYSIS AND
CHEMO PATIENTS
THESE PT'S ARE ANEMIC, SO GIVEN EPO TO STIMULATE ERYTHROPOIESIS
GIVEN SEVERAL TIMES PER WEEK
GOAL TO INCREASE HEMATOCRIT TO 33%
WHAT IS THE LAST IMMATURE FORM OF THE ERYTHROBLAST? - ANSWER:
RETICULOCYTE
MEASURING A RETICULOCYTE COUNT IS A GOOD INDICATOR OF WHAT? - ANSWER:
ERYTHROPOIESIS (NEW RBC'S BEING MADE)
WHAT IS HEMOGLOBIN? - ANSWER: OXYGEN CARRYING PORTION OF THE RBC'S
NORMAL HEMOGLOBIN - ANSWER: 13-16GM/DL
WHAT MOLECULE IS ATTACHED TO HEME ON HEMOGLOBIN? - ANSWER: OXYGEN
EACH HEMOGLOBIN MOLECULE HAS HOW MANY GLOBIN CHAINS? - ANSWER: 2
EACH HEMOGLOBIN MOLECULE HAS HOW MANY COMPLEXES OF IRON AND HEME?
- ANSWER: 4
WHERE IS HEME SYNTHESIZED? - ANSWER: MITOCHONDRIA
HEME CARRIES HOW MANY OXYGEN MOLECULES? - ANSWER: 1
EVERY MOLECULE OF HEMOGLOBIN CARRIES HOW MANY OXYGEN? - ANSWER: 4
WHAT IS GLOBIN? - ANSWER: PROTEIN THAT CONTAINS HEME
MOST COMMON GLOBIN CHAIN? - ANSWER: HGB-A
2 ALPHA CHAINS
, 2 BETA CHAINS
WHAT DO RBC'S USE FOR ENERGY? - ANSWER: GLYCOLYSIS
DO RBC'S HAVE MITOCHONDRIA? - ANSWER: NO
THUS, NO ATP
TRANSFERRIN TURNS TO WHAT? - ANSWER: FERRITIN
G6PD DOES WHAT? - ANSWER: PROTECTS RBC'S AGAINST OXIDATIVE STRESS
WHAT IS ANEMIA? - ANSWER: REDUCTION IN THE TOTAL NUMBER OF
ERYTHROCYTES IN THE CIRCULATING BLOOD
ANISOCYTOSIS? - ANSWER: RBC'S ARE VARIOUS SIZES
POIKLOCYTOSIS? - ANSWER: RBC'S ARE VARIOUS SHAPES
IRON-DEFICIENCY ANEMIA PATHO - ANSWER: INADEQUATE DIETARY INTAKE
BLOOD LOSS
PARASITE INFECTIONS
MENORRHAGIA*
GI BLEED*
IRON-DEFICIENCY CLINICAL MANIFESTATIONS - ANSWER: COGNITIVE IMPAIRMENT
IN CHILDREN
NO SYMPTOMS MILD ANEMIA
DYSNPLEA
PICA* (PREGNANT LADIES)
LAB VALUES FOR IRON DEFICIENCY ANEMIA - ANSWER: LOW FERRITIN (MOST
SENSITIVE TEST FOR IDA)
LOW SERUM IRON
HIGH TIBC****
IF THERE IS NOT ENOUGH IRON TO BIND TO TRANSFERRIN, WILL THE TIBC BE HIGH
OR LOW? - ANSWER: HIGH TIBC
SIDEROBLASTIC ANEMIA PATHO - ANSWER: PROBLEM WITH HEME
DEFECT IN MITOCHONDRIAL HEME SYNTHESIS*
DYSFUNCTIONAL HEMOGLOBIN SYNTHESIS*
SIDEROBLASTIC ANEMIA CLINICAL MANIFESTATIONS - ANSWER: IRON OVERLOAD
ENLARGED SPLEEN AND LIVER
ETOH ABUSE
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